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Angiotensin-[1-9], the product of angiotensin I conversion in platelets, enhances arterial thrombosis in rats

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Kramkowski K., Mogielnicki A., Leszczynska A., Buczko W.

Journal of Physiology and Pharmacology

2010

tom 61

nr 3

317-324

Angiotensin (Ang) (1-9) is the renin-angiotensin-system peptide found in the plasma of healthy volunteers and after angiotensin-converting-enzyme inhibitors therapy. In vitro experiments proved that Ang-(1-9) may be produced from Ang I. In our study, we tried to expand the poor data about the in vivo properties of Ang-(1-9). We revealed that Ang-(1-9) enhanced electrically stimulated arterial thrombosis in the carotid artery of Wistar rats. Losartan, a selective blocker of AT1 receptor for Ang II, abolished the prothrombotic activity of Ang-(1-9). This peptide increased plasma level of fibrinogen, augments fibrin generation, and similarly to Ang II, potentiated collagen induced platelet aggregation. Using HPLC, we found that after incubation of Ang-(1-9) with platelet homogenates or after intravenous administration this peptide is converted to Ang II. We concluded that Ang-(1-9) exerts an Ang II-like prothrombotic effect due to the conversion to Ang II in the circulatory system of rats and that platelets are involved in this process.

Ograniczanie wyników

1 Journal of Physiology and Pharmacology

1 Buczko W.

1 Kramkowski K.

1 Leszczynska A.

1 Mogielnicki A.

1 2010

Wyniki wyszukiwania

Angiotensin-[1-9], the product of angiotensin I conversion in platelets, enhances arterial thrombosis in rats