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Magnesium in pathophysiology and therapy of affective disorders

100%

Poleszak E., Nowak G.

Journal of Elementology

2006

tom 11

nr 3

p.389-397,fig.,ref.

Magnesium possesses activity in a broad range of biochemical processes in living organisms. This review focus on the role of magnesium in pathophysiological and therapeutical mechanisms of affective disorders. Magnesium as an antagonist of the N-methyl-D- -aspartate (NMDA)/glutamate receptor complex, is active in the antidepressant screen test, forced swim test in rodents. Clinical studies, although providing very limited amount of data, suggest possible efficacy of magnesium in mania (bipolar affective disorders). Magnesium deficiency induced depression-like behavior in animals, and such an effect in humans is also suggested. All the available data indicate the importance of magnesium homeostasis in pathophysiology and therapy of affective disorders.

Ograniczanie wyników

1 Journal of Elementology

1 Nowak G.

1 Poleszak E.

1 2006

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Magnesium in pathophysiology and therapy of affective disorders