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Antipyretic activity of prazosin

100%

Szreder Z.

Acta Physiologica Polonica

1990

tom 41

nr 1-3

Szreder Z.: Antipyretic activity of prazosin. Acta Physiol. Pol. 1990, 41, (1 3): 45-52. Thermal responses to prazosin (0.75 mg/kg, i.v. as a bolus injection or 3 h infusion) were investigated in febrile rabbits (treated with E. coli lipopolysaccharide, PLPS) at 3 ambient temperatures (Ta) of 5, 19, 28° C. The drug produced antipyresis which increased with the simultaneous drop of Ta. This antipyretic activity was accompanied by an inhibition of heat production or enhanced elimination of heat, depending on Ta. It is suggested that antipyresis produced by prazosin is mainly due to the effector part of the thermoregulatory system.

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Influence of an early adrenergic blockade on thrombotic infarct size and myocardial metabolism

51%

Zmudka K., Dubiel J., Pieniazek P., Dudek D., Kocurek A., Trebacz J., Grodecki J., Flameng W., De Geest H.

Journal of Physiology and Pharmacology

1998

tom 49

nr 3

Ograniczanie wyników

1 Acta Physiologica Polonica

1 Journal of Physiology and Pharmacology

1 De Geest H.

1 Dubiel J.

1 Dudek D.

1 Flameng W.

1 Grodecki J.

1 Kocurek A.

1 Pieniazek P.

1 Szreder Z.

1 Trebacz J.

1 Zmudka K.

1 1998

1 1990

Wyniki wyszukiwania

Antipyretic activity of prazosin

Influence of an early adrenergic blockade on thrombotic infarct size and myocardial metabolism