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Transcriptional upregulation of gastrin in response to peroxisome proliferator-activated receptor gamma agonist triggers cell survival pathways

100%

Ptak-Belowska A., Pawlik M. W., Krzysiek-Maczka G., Brzozowski T., Pawlik W. W.

Journal of Physiology and Pharmacology

2007

tom 58

nr 4

Peroxisome proliferator-activated receptor (PPAR ) are members of the largest nuclear hormone receptor family of transcription factors (1). PPAR gamma (PPAR) plays an important role in adipogenesis, control of sensitivity to insulin, inflammation and atherosclerosis but recent studies also suggest that PPAR is involved in cell cycle withdrawal. PPAR can promote cell differentiation, exert an antiproliferative action and inhibit angiogenesis (2, 3). However, there are studies showing that activation of PPAR promotes the development of colon cancer (4). These data are in sharp contrast with studies that attribute anticancer effects to PPAR in gastrointestinal malignancies. Probably, the action of PPAR on cell cycle and proliferation depends on the cell type and presence of other stimuli that predispose cells to cancer development. Amidated and non-amidated gastrins may play an important role in the proliferation and carcinogenesis of GI cancers. It is known that gastrin peptides activate phosphorylation of Protein Kinase B (PKB/Akt) and anti-apoptotic signalling but there is little known about the link between gastrins and PPAR receptors in relation to apoptosis.

The human immunodeficiency virus (HIV1) protease inhibitor sanquinavir activates autophagy and removes lipids deposited in lipid droplets

84%

Polus A., Bociaga-Jasik M., Czech U., Goralska J., Cialowicz U., Chojnacka M., Polus M., Jurkowski K., Dembinska-Kiec

Journal of Physiology and Pharmacology

2017

tom 68

nr 2

The adipocyte component of bone marrow in heterotopic bone induced by demineralized incisor grafts

84%

Wlodarski K. H., Galus R., Brodzikowska A., Wlodarski P. K.

Folia Histochemica et Cytobiologica

2012

tom 50

nr 3

Ograniczanie wyników

2 Journal of Physiology and Pharmacology

1 Folia Histochemica et Cytobiologica

1 Bociaga-Jasik M.

1 Brodzikowska A.

1 Brzozowski T.

1 Chojnacka M.

1 Cialowicz U.

1 Czech U.

1 Dembinska-Kiec

1 Galus R.

1 Goralska J.

1 Jurkowski K.

1 Krzysiek-Maczka G.

1 Pawlik M. W.

1 Pawlik W. W.

1 Polus A.

1 Polus M.

1 Ptak-Belowska A.

1 Wlodarski K. H.

1 Wlodarski P. K.

1 2017

1 2012

1 2007

Wyniki wyszukiwania

Transcriptional upregulation of gastrin in response to peroxisome proliferator-activated receptor gamma agonist triggers cell survival pathways

The human immunodeficiency virus (HIV1) protease inhibitor sanquinavir activates autophagy and removes lipids deposited in lipid droplets

The adipocyte component of bone marrow in heterotopic bone induced by demineralized incisor grafts