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Effects of antibiotics on acquired immunity in vivo - current state of knowledge

100%
Pomorska-Mol M., Pejsak Z.
Polish Journal of Veterinary Sciences
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2012
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tom 15
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nr 3
Antibiotics are widely used in the therapy of infections. Besides the respective interactions between antibiotics and pathogens it seems that antibiotics also directly interact with the immune system. Some commonly used antibiotics are currently known to have effects on the innate immune response, as shown by in vitro, ex vivo and also in vivo animal experiments and clinical studies. Most of the experimental papers published to date, as well as most reviews, relate to how antibiotics affect the innate immune response or non-specific monocyte or lymphocyte proliferation. However the effects of antibiotics on the adaptive immune response are still not well characterized. This review of the literature considering different in vivo experiments indicate the real importance of interrelations existing between acquired immune responses and antibiotics, however, the mechanism of immunomodulatory effects of antibiotics are still poorly understood. Currently, data on the immunomodulating effects of antibiotics often remain heterogeneous, contradictory or insufficient, but most results published to date revealed the immunosuppressive effect of antibiotics on the antigen- specific immune response in vivo. In pigs as well as in poultry herds, it is not uncommon practice to add antibiotics to drinking water or feed at the time of vaccination. Information on the effects of such practices on the immune system of animals is restricted and more in vivo studies are needed to investigate the effects of antimicrobial drugs on the immune system, especially in the field conditions.
2

Immune response of cats experimentally infected with Microsporum canis

86%
Wawrzkiewicz K., Ziolkowska G., Sadzikowski Z., Stepien M.
Polish Journal of Veterinary Sciences
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2000
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tom 03
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nr 2
The aim of this study was an assessment of the immune response of cats experimentally infected with M. canis and a determination of the extent of immunity acquired after recovery. Studies were carried out on 24 domestic, short-haired cats, aged 3-4 months. The resistance of the animals was assessed by reinfection, and the degree of immune response. It has been found that after recovery from an experimental infection with M. canis, the cats which remained in an infected environment for 18 weeks showed no clinical mycotic changes, whereas control animals underwent natural infection within 6 weeks and their mycosis had a typical course. Furthermore reinfection with high doses of the fungus and skin scarification failed to break down this acquired immunity. Hypersensitivity of the delayed type, encountered in cats within 3 weeks after the experimental infection, persisted for 8 months of studies. In an analogous period of time cats infected naturally demonstrated an evidently weaker response determined by the skin test. Positive results of the migration inhibition test were obtained in the period of 3-6 weeks after infection, which corresponded with the period of the persistence of the clinical mycotic changes.
3

Układ immunologiczny - naturalny sprzymierzeniec lekarza w walce z chorobami

44%
Pomorska-Mol M.
Lecznica Dużych Zwierząt. Ogólnopolski Kwartalnik dla Lekarzy Weterynarii
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2014
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tom 09
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nr 1
4

Skutki immunosupresji wywołanej przez mikotoksyny w etiologii wybranych chorób zakaźnych świń

44%
Pejsak Z., Truszczynski M.
Lecznica Dużych Zwierząt. Ogólnopolski Kwartalnik dla Lekarzy Weterynarii
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2015
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tom 10
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nr 1
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