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The influence of social support on the occurrence of the withdrawal syndrome in alcohol abused patients

100%

Bargiel-Matusiewicz K., Ziebaczewska M.

Journal of Physiology and Pharmacology. Supplement

2006

tom 57

nr 4

23-31

The current investigation concerns the connection between social support given to alcohol abused patients and the occurrence of the withdrawal syndrome experienced by them, resulting from emotional and physical uneasiness. The independent variable, which was social support, has been formulated in a qualitative way, by referring to such subjective measures as: feeling of support, its perceived availability, and adequacy. The survey pattern was prepared on the basis of the claim of existence of the so-called main effect, i.e., direct relationship between social support and individual's psychophysical comfort. The investigated variables were measured using the following research tools: The Scale of Social Support and Clinical Institute Withdrawal Assessment for Alcohol-revised (CIWA-Ar). The results clearly show the dependence between the level of social support and the intensity of the withdrawal syndrome in alcohol abused patients. Apart from a cognitive value of the fact, it is worth paying attention to a possibility of its practical application.

The effect of an endogenous compound 1-methyl-1,2,3,4-tetrahydroisoquinoline on morphine-induced analgesia, dependence and neurochemical changes in dopamine metabolism in rat brain structures

84%

Wasik A., Romanska I., Antkiewicz-Michaluk L.

Journal of Physiology and Pharmacology

2007

tom 58

nr 2

1,2,3,4-Tetrahydroisoquinolines, among them the most interesting neuroprotective substance, an inhibitor of MAO, 1-methyl-1,2,3,4-tetrahydroisoquinoline (1MeTIQ), are endogenous compounds present in the central nervous system of mammals and humans. In this study, we investigated the effect of 1MeTIQ on morphine-induced analgesia, tolerance and abstinence syndrome as well as its effect on morphine-induced changes in dopamine metabolism in rat brain structures (nucleus accumbens, striatum, substantia nigra) using HPLC methodology. The experiments were carried out on male Wistar rats. Morphine analgesia was measured in the “hot-plate” test. To induce tolerance, morphine was given chronically (20 mg/kg i.p.) alone or following 1MeTIQ (50 mg/kg i.p.) injection. The development of dependence was assessed in the naloxone (2 mg/kg i.p.) precipitation test, after 10 days of morphine administration. The behavioral studies have shown that an endogenous compound, 1MeTIQ produced strong potentiation of morphine analgesia, prevented the development of morphine tolerance and inhibited expression of morphine abstinence syndrome in morphine-dependent rats. In neurochemical studies, we have demonstrated that 1MeTIQ antagonized morphine-induced changes in dopamine metabolism observed in rat brain structures. The main finding of this study was demonstration for the first time of an anti-abuse effect of an endogenous compound, 1MeTIQ, and its efficiency in counteracting morphine-induced addiction in the way useful from clinical point of view. The obtained results suggested a possibility of clinical application of 1MeTIQ in morphine addiction.

Ograniczanie wyników

1 Journal of Physiology and Pharmacology

1 Journal of Physiology and Pharmacology. Supplement

1 Antkiewicz-Michaluk L.

1 Bargiel-Matusiewicz K.

1 Romanska I.

1 Wasik A.

1 Ziebaczewska M.

1 2007

1 2006

Wyniki wyszukiwania

The influence of social support on the occurrence of the withdrawal syndrome in alcohol abused patients

The effect of an endogenous compound 1-methyl-1,2,3,4-tetrahydroisoquinoline on morphine-induced analgesia, dependence and neurochemical changes in dopamine metabolism in rat brain structures