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Chemical composition and antifungal activities of Ziziphora tenuior and Z. clinopodioides essential oils against dermatophytes

100%

Mahboubi M., Tabar R. H., Mahdizadeh E.

Herba Polonica

2018

tom 64

nr 2

Ziziphora species are traditionally used for treatment of different infectious and non-infectious diseases as antiseptic agents. The aim of this study was to evaluate the chemical composition of Ziziphora clinopodioides and Z. tenuir essential oils and their antifungal effects againt five strains of dermatophytes. GC and GC-MS methods were used for essentional oils analize. The anti-elastase activities were determined by porcine pancreatic elastase assays. 48 different compounds were identified in these two essential oils, which thymol, p-cymene, 1,8-cineole and γ-terpinene were their major components. The anti-dermatophyte activities of essential oils against dermatophytes showed that the essential oils (150 ppm) inhibited the mycelium growth, about 5–100%, which Z. clinopodioides essential oil had higher mycelium growth inhibition (28–100%) than that of Z. tenuir oil. The MIC and MFC values of essential oils were 0.01–1 μl/ml. 0.5 μl/ml essential oils inhibited porcine pancreatic elastase, dose-dependently. Due to the anti-dermatophyte and anti-elastase effects of Ziziphora sp., it can be considered as natural antifungal agent for more clinical and pre-clinical trials.

Ograniczanie wyników

1 Herba Polonica

1 Mahboubi M.

1 Mahdizadeh E.

1 Tabar R. H.

1 2018

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Chemical composition and antifungal activities of Ziziphora tenuior and Z. clinopodioides essential oils against dermatophytes