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Cytotoxic flavonoids from Diplotaxis harra (Forsk.) Boiss. growing in Sinai

100%

Mohammed M. M. D., El-Sharkawy E. R., Matloub A. A.

Herba Polonica

2011

tom 57

nr 3

As a part of our ongoing collaborative effort to discover the anticancer activity of the phenolics isolated from terrestrial plant sources, the EtOH extract of the aerial parts of the Egyptian medicinal plant Diplotaxis harra (Forsk.) Boiss. was in vitro investigated for its cytotoxicity against HCT116, HepG2 and MCF-7 cell lines, and resulted with IC50=4.65, 12.60 and 17.90 μg/ml, respectively. Doxorubicin (+ve control) showed in vitro cytotoxic activity with IC50=3.64, 4.57 and 2.97 μg/ml, respectively. The phenolic-rich fraction of the EtOH extract was subjected to further fractionation, which led to the isolation of five flavonoids identified as quercetin, quercetin 3-O-β-glucoside, isorhamnetin 7-O-β-glucoside, apigenin 3-O-β-rhamnoside and kaempferol 3-O-β-glucoside, according to its’ spectral data and comparison with the literature. Furthermore, the isolated flavonoids showed in vitro cytotoxicity against HCT116 cell line with IC50=20.1, 24.3, 22.8, 23.4 and 41.9 μg/ml as determined by MTT method.

Actual evapotranspiration of the orange orchard in Northern Sinai, Egypt

84%

Nizinski J. J., Ziernicka-Wojtaszek A., Ksiazek L., Gawronski K., Montoroi J.-P., Zaghloul A., Ali R. R., Saber M.

Acta Scientiarum Polonorum. Formatio Circumiectus

2017

tom 16

nr 4

Weed communities of date-palm orchards in the Feiran Oasis [South Sinai, Egypt

84%

El-Ghani M. M. A.

Fragmenta Floristica et Geobotanica

1998

tom 43

nr 2

Comparison of the impacts of climate change and anthropogenic disturbances on the El Arish coast and seaweed vegetation after ten years in 2010, North Sinai, Egypt

59%

El Shoubaky G. A.

Oceanologia

2013

tom 55

nr 3

Ograniczanie wyników

1 Acta Scientiarum Polonorum. Formatio Circumiectus

1 Fragmenta Floristica et Geobotanica

1 Herba Polonica

1 Oceanologia

1 Ali R. R.

1 El Shoubaky G. A.

1 El-Ghani M. M. A.

1 El-Sharkawy E. R.

1 Gawronski K.

1 Ksiazek L.

1 Matloub A. A.

1 Mohammed M. M. D.

1 Montoroi J.-P.

1 Nizinski J. J.

1 Saber M.

1 Zaghloul A.

1 Ziernicka-Wojtaszek A.

1 2017

1 2013

1 2011

1 1998

Wyniki wyszukiwania

Cytotoxic flavonoids from Diplotaxis harra (Forsk.) Boiss. growing in Sinai

Actual evapotranspiration of the orange orchard in Northern Sinai, Egypt

Weed communities of date-palm orchards in the Feiran Oasis [South Sinai, Egypt

Comparison of the impacts of climate change and anthropogenic disturbances on the El Arish coast and seaweed vegetation after ten years in 2010, North Sinai, Egypt