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1

Wplyw Lydium KLP i LPS na regulacje temperatury oraz odpowiedz humoralna u krolikow

100%
Mukezamfura P., Fiolka M., Zieba P., Studzinski T.
Medycyna Weterynaryjna
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1996
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tom 52
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nr 12
783-785
Lydium KLP (dimer lysozyme) used in veterinary practice as an immunostimulator has different effects of action on humoral immunity of rabbits compared with endotoxin (LPS) activity. E. coli endotoxin (Kroeger O8) given intravenously induced humoral immunity in rabbits after its first injection while the first administration of Lydium KLP hardly stimulated humoral immunity in comparison to the second dose. LPS is commonly regarded as a pirogen while Lydium KLP is not. The results obtained indicate different effects of Lydium KLP and LPS on antibody production and on temperature release.
2

Przydatnosc dimeru lizozymu w leczeniu endometritis klaczy

100%
Wisniewski E., Czerwonka R., Czerwonka B.
Medycyna Weterynaryjna
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2003
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tom 59
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nr 02
124-127
3
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Influence of Lydium KPL upon morphology of lung tissue and serum cytokine level in irradiated rats

100%
Staroslawska E., Roszkowski J., Kozaczynski W., Donica H., Bachanek T., Jarmolinska K., Bozyk A., Moskwa A.
Bulletin of the Veterinary Institute in Puławy
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2001
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tom 45
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nr 1
The modifying influence of Lydium KLP upon the early postirradiation reaction in rats was studied. The effects of Lydium KLP upon the intensity of irradiation reaction was monitored in morphological examinations of the trachea and lung tissue and concentrations of chosen blood plasma proinflammatory cytokines. The experiment was carried out on four groups of Wistar rats: (1) not irradiated (control), (2) administered with Lydium KLP, (3) irradiated and (4) irradiated with Lydium KLP administration. After three months the animals were sacrificed and histopathological examinations of the trachea and lung sections were performed. The concentrations of TNFa, IL-6 chemotactic factor MIP-2 were determined with commercial kits. It was found that postirradiation reduced the damage of the trachea and lung tissue in the group of rats irradiated with simultaneous administration of Lydium KLP. However, the concentrations of proinflammatory cytokines in the group of rats irradiated with simultaneous administration of Lydium KLP were higher in comparison to the group irradiated, not treated with Lydium KLP.
4

Effect of the coupled administration of Lydium-KLP or methisoprinol and respisure on the health status and prevention of mycoplasmal pneumonia of swine in large-scale commercial breeding

80%
Procajlo Z., Szweda W., Mikulska-Skupien E., Platt-Samoraj A.
Bulletin of the Veterinary Institute in Puławy
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2010
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tom 54
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nr 1
9-14
The study was aimed on determining the clinical protective value of Lydium-KLP and Methisoprinol in the prevention of respiratory system diseases, as well as their effect on the health status of pigs in large-scale commercial breeding and on the improvement of in the effectiveness of specific immunoprophylaxis of mycoplasmal pneumonia of in swine (MPS). Piglets at the age of 7 d were divided into eight groups of 25-30 piglets each. On days 7 and 21 of life they were immunised with Respisure vaccine (group I) or administrated Lydium-KLP or Methisoprinol (groups IV and VII). In other groups, Lydium-KLP or Methisoprinol were given simultaneously (groups II and V) or 48 h before immunisation with Respisure (groups III and VI). Control piglets were administrated PBS (group C). Clinical observations as well as post-slaughter and animal husbandry analyses indicated that the simultaneous administration of Lydium-KLP or Methisoprinol with Respisure gives better results in comparison to immunisation- only with Respisure. The statistically-significant differences were found in the mean percentage of meatiness between groups receiving Methisoprinol with or 48 h before Respisure and control group, as well as in the point evaluation of lesions in the lungs between groups receiving Lydium-KLP with Respisure and Methisoprinol 48 h before Respisure and control group. The study demonstrated the beneficial effect of coupled administration of Lydium-KLP or Methisoprinol and Respisure on the improvement of health status and the productive performance of pigs, as well as on the effectiveness of specific immunoprophylaxis of MPS in large- scale commercial breeding. The most beneficial variants of coupled administration were the simultaneous application of Lydium- KLP and Respisure, and Methisoprinol application 48 h before immunisation with Respisure.
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