Clinical nad laboratory investigations in a barn of 150 Polish - merino sheep indicated eperythrozoonosis. Clinical symptoms noted in 11 animals from a few months to 2 years of age were manifested by apathy, anorexia, hyposthenia, pale and yellow colored conjunctivae and increased internal body temperature. During the first week after the appearance of clinical symptoms 4 animals died. Gross pathological lesions included the pale color of mucosal membranes, an enlarged and brittle liver (yellow), the increased volume of visceral and pleural exudate, and yellow or bloody exudate in the pericardial sac. The red blood cell count (RBC), content of hemoglobin (HOM) and mean hemoglobin concentration (MCHC) and hematocrit value (HCI) significantly decreased. Microscopic examination of blood smears stained by the LYM method increased the white blood cell count (WBC), including the percentage of lymphocytes (LYM). In blood smears stained by Giemsa Eperythrozoon sp. were found in red blood cells.