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1

Cytokines and costimulatory molecules: positive and negative regulation of the immune response to Cryptococcus neoformans

100%

Vecchiarelli A.

Archivum Immunologiae et Therapiae Experimentalis

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2000

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tom 48

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nr 6 Spec.Iss.

2

Fungi pathogenic to humans: molecular bases of virulence of Candida albicans, Cryptococcus neoformans and Aspergillus fumigatus

84%

Karkowska-Kuleta J., Rapala-Kozik M., Kozik A.

Acta Biochimica Polonica

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2009

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tom 56

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nr 2

211-224

The frequency of severe systemic fungal diseases has increased in the last few decades. The clinical use of antibacterial drugs, immunosuppressive agents after organ transplantation, cancer chemotherapy, and advances in surgery are associated with increasing risk of fungal infections. Opportunistic pathogens from the genera Candida and Aspergillus as well as pathogenic fungi from the genus Cryptococcus can invade human organism and may lead to mucosal and skin infections or to deep-seated mycoses of almost all inner organs, especially in immunocompromised patients. Nowadays, there are some effective antifungal agents, but, unfortunately, some of the pathogenic species show increasing resistance. The identification of fungal virulence factors and recognition of mechanisms of pathogenesis may lead to development of new efficient antifungal therapies. This review is focused on major virulence factors of the most common fungal pathogens of humans: Candida albicans, Aspergillus fumigatus and Cryptococcus neoformans. The adherence to host cells and tissues, secretion of hydrolytic enzymes, phenotypic switching and morphological dimorphism contribute to C. albicans virulence. The ability to grow at 37°C, capsule synthesis and melanin formation are important virulence factors of C. neoformans. The putative virulence factors of A. fumigatus include production of pigments, adhesion molecules present on the cell surface and secretion of hydrolytic enzymes and toxins.

3

Kryptokokoza układu nerwowego - wyzwanie diagnostyczne i terapeutyczne dla lekarza weterynarii

67%

Kwiatkowska M., Pomianowski A.

Magazyn Weterynaryjny

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2012

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tom 21

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nr 01

4

Artykuł dostępny w postaci pełnego tekstu - kliknij by otworzyć plik

Taxonomic diversity of potentially pathogenic fungi constituting a risk to children’s health isolated from sandpits in Lodz

67%

Goralska K., Kurnatowski P., Blaszkowska J., Wojcik A.

Annals of Parasitology

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2016

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tom 62

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nr Suppl.

5

Rzekomy pomor drobiu, choroba ptasia, kryptokokoza histoplazmowa

67%

Glinski Z., Luft-Deptula D.

Polskie Drobiarstwo

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2003

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nr 01

9-11

6

Rezonans magnetyczny i spektroskopowa ocena metabolitow tkanki mozgowej w przebiegu kryptokokozy OUN

67%

Wiercinska-Drapalo A., Tarasow E.

Wiadomości Parazytologiczne

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2001

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tom 47

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nr 3

535-541

Cryptococcus neoformans is the causative agent of cryptococcosis and cryptococcal meningitis, which are serious pathological conditions affecting up to 10% of patients with AIDS. In this paper we present results magnetic resonance imaging and spectroscopic metabolites (1H MR) in brain cryptococcosis. In 1HMR spectroscopy we tind decreased metabolic ratios to nonsaturated water (H2O) signal N-acetylaspartate (NA/H20, creatine (Cr/H20), choline (Cho/H20). We show increased mioinositol to H2O ratio. Spectroscopy results suggest about massive neuronal injury and accompanying gliosis in brain cryptococcosis.

7

Cryptococcus neoformans: occurrence in human environment and virulence factors

67%

Kwasniewska J.

Wiadomości Parazytologiczne

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1998

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tom 44

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nr 3

8

Ocena stanu zdrowotnego stada podstawowego lisow polarnych na wybranych fermach w Polsce

43%

Szeleszczuk O., Kilar P.

Przegląd Hodowlany

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2010

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tom 78

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nr 05

20-25

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