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Definition of immunogenic carbohydrate epitopes

100%

Paschinger K., Fabini G., Schuster D., Rendic D., Wilson I. B. H.

Acta Biochimica Polonica

2005

tom 52

nr 3

Carbohydrates are known as sources of immunological cross-reactivity of allergenic significance. In celery and in cypress pollen, the major allergens Api g 5 and Cup a 1 are recognised by antisera raised against anti-horseradish peroxidase and by patients' IgE which apparently bind carbohydrate epitopes; mass spectrometric analysis of the tryptic peptides and of their N-glycans showed the presence of oligosaccharides carrying both xylose and core α1,3-fucose residues. Core α1,3-fucose residues are also a feature of invertebrates: genetic and biochemical studies on the fruitfly Drosophila melanogaster, the parasitic trematode Schistosoma mansoni and the nematode worm Caenorhabditis elegans indicate that these organisms possess core α1,3-fucosyltransferases. Various experiments have shown that fucosyltransferases from both fly and worm are responsible in vivo and in vitro for the synthesis of N-glycans which cross-react with anti-horseradish peroxidase; thus, we can consider these enzymes as useful tools in generating standard compounds for testing cross-reactive carbohydrate epitopes of allergenic interest.

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Human genome sequenced: achievements and shortcomings in big science

80%

Blin N.

Journal of Applied Genetics

2001

tom 42

nr 4

Ograniczanie wyników

1 Acta Biochimica Polonica

1 Journal of Applied Genetics

1 Blin N.

1 Fabini G.

1 Paschinger K.

1 Rendic D.

1 Schuster D.

1 Wilson I. B. H.

1 2005

1 2001

Wyniki wyszukiwania

Definition of immunogenic carbohydrate epitopes

Human genome sequenced: achievements and shortcomings in big science