The purpose of this work was to evaluate under experimental conditions the clinical and economic of the combined use of tiamulin and tetracycline in the treatment of mixed infections of the respiratory system. Sixteen piglets, approximately 12 kg, were used in the experiment. The animals were free of Mycoplasma hyopneumoniae (M.hp.), Bordetella bronchiseptica (B.b.), Pasteurella multocida (P.m.) and Actinobacillus pleuropneumoniae (A.pp). The piglets were infected at day „0” with an M.hp. suspension at a dose of 10⁷ cfu/ml. One ml of this suspension was given into each nostril. After 14 days the animals were randomly divided into 2 groups (experimental I and control II) and infected with a suspension of dermonecrotoxic strain of P.m. The density of this culture was 10⁹ cfu/ml. Two ml of this suspension was administered into each nostril. On the same day treatment of the experimental group was started using doses of tiamulin and tetracycline recomended by the producer. After 10 days treatment was finished. Six weeks after the P.m. infection all sows were killed. The efficacy of the therapy was evaluated on the basis of bacteriological and serological examinations and post mortem findings: estimation of lesions in the lungs, isolation of M.hp. and P.m. from lung tissue. The dynamics of body weight gains and feed conversion were also determined. After investigation it was determined that administration of the above mentioned antibiotics eliminated M.hp. and P.m. in all animals from the experimental group. In the control group M.hp. was isolated in 3 cases and P.m. in 5 cases. There were considerable visible differences in the spread of lesions in lungs from treated and untreated sows. Mean body weight at the day of slaughter in the experimental group was about 6.5 kg higher than in the control. There were significant differences in dynamics of body weight gains visible in the whole period between P.m. infection and the day of slaughter. Feed conversion was also about 20% better in the treated group. It was concluded that tiamulin and tetracycline combination was effective in the therapy of experimentally induced, mixed infection of the respiratory system of pigs.
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