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Synthesis and antimicrobial activity of new adamantane derivatives I

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Orzeszko A., Gralewska R., Starosciak B. J., Kazimierczuk Z.

Acta Biochimica Polonica

2000

tom 47

nr 1

A series of fourteen derivatives of adamantane was synthesised. The new compound 4-(adamant-1-ylmethoxycarbonyl)phthalanhydride obtained from 1-adamantane- methanol and trimellitic anhydride chloride appeared very useful for preparation of a number of N-substituted phthalimides. Antimicrobial activity of the newly obtained derivatives such as, for example, 4-(adamant-1-ylmethoxycarbonyl)-N-(5-carboxypentamethylene)phthalimide or 4-(adamant-1-ylmethoxycarbonyl)-N-(L-alanyl)phthalimide was tested against Staphylococcus aureus, Bacillus sp., Micrococcus flavus and Enterococcus faecium. The minimal inhibitory concentration (MIC) for these compounds against S. aureus were 0.022 and 0.05 µg/ml, respectively.

Ograniczanie wyników

1 Acta Biochimica Polonica

1 Gralewska R.

1 Kazimierczuk Z.

1 Orzeszko A.

1 Starosciak B. J.

1 2000

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Synthesis and antimicrobial activity of new adamantane derivatives I