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Dissociation of parathyroid hormone and cyclic-3',5'AMP effects on Na-Pi uptake by cells isolated from proximal straight tubules of rat kidney

100%

Rybczynska A., Angielski S., Hoppe A.

Journal of Physiology and Pharmacology

2000

tom 51

nr 2

Hydrolysis cyclic GMP in rat peritoneal macrophages

100%

Witwicka H., Kobialka M., Gorczyca W. A.

Acta Biochimica Polonica

2002

tom 49

nr 4

Intact rat peritoneal macrophages (rPM) treated with 3-isobutyl-1-methylxanthine (IBMX), an inhibitor of phosphodiesterases (PDEs), accumulated more cGMP than untreated cells. A PDE activity toward [3H]cGMP was detected in the soluble and particulate fractions of rPM. The hydrolysis of cGMP was Ca2+ /calmodulin-independent but increased in the presence of cGMP excess. Similar results were obtained when3 [ 3H]cAMP was used as a substrate. The hydrolytic activity towards both nucleotides was inhibited in the presence of IBMX. Therefore, the PDEs of families 2,5,10 and 11 are potential candidates for cGMP hydrolysis in the rPM. They may not only regulate the cGMP level in a feedback-controlled way but also link cGMP-dependent pathways with those regulated by cAMP.

Ograniczanie wyników

1 Acta Biochimica Polonica

1 Journal of Physiology and Pharmacology

1 Angielski S.

1 Gorczyca W. A.

1 Hoppe A.

1 Kobialka M.

1 Rybczynska A.

1 Witwicka H.

1 2002

1 2000

Wyniki wyszukiwania

Dissociation of parathyroid hormone and cyclic-3',5'AMP effects on Na-Pi uptake by cells isolated from proximal straight tubules of rat kidney

Hydrolysis cyclic GMP in rat peritoneal macrophages