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Effect of HMB and 2-Ox administered during pregnancy on bone properties in primiparous and multiparous minks (Neovison vison)

100%

Tomaszewska E., Dobrowolski P., Kostro K., Jakubczak A., Taszkun I., Jaworska-Adamu J., Zmuda A., Rycerz K., Muszynski S.

Bulletin of the Veterinary Institute in Puławy

2015

tom 59

nr 4

The aim of the study was to determine the mechanical and geometric properties as well as bone tissue density of long bones in primiparous and multiparous dams of minks supplemented with ß-hydroxy ß-methylbutyrate (HMB) and/or 2-oxoketoglutarate (2-Ox) during gestation. Powdered 2-Ox was given at the daily dosage of 0.4 g/kg b.w. separately or simultaneously with HMB, which was administered at the daily dosage of 0.02 g/kg b.w. The study demonstrates for the first time that administration of 2-Ox and/or HMB to dams markedly influences bone tissue density and the mechanical and geometrical properties of mother's bones in minks. Moreover, it was demonstrated that the supplementation was more effective in the thoracic limb, which was comprehensively used in contrast to the pelvic limb. The mechanical parameters and bone tissue density significantly increased in the humerus in multiparous minks. Only such diet may provide satisfactory production results in the animals. Nutritional deficiencies occurring during pregnancies may trigger body's own reserves to cover the bone mass increase in developing foetuses and support milk production. This can prevent regeneration of dams' organisms, which negatively affects their reproductive performance. 2-Ox or HMB may be regarded as a protective metabolite when administered orally to minks, counteracting the negative influences of pregnancy and lactation periods on bones condition. Both simultaneous treatment with 2-Ox and HMB and their separate administration were equally effective.

Postnatal administration of 2-oxoglutaric acid improves articular and growth plate cartilages and bone tissue morphology in pigs prenatally treated with dexamethasone

80%

Tomaszewska E., Dobrowolski P., Wydrych J.

Journal of Physiology and Pharmacology

2012

tom 63

nr 5

Ograniczanie wyników

1 Bulletin of the Veterinary Institute in Puławy

1 Journal of Physiology and Pharmacology

2 Dobrowolski P.

2 Tomaszewska E.

1 Jakubczak A.

1 Jaworska-Adamu J.

1 Kostro K.

1 Muszynski S.

1 Rycerz K.

1 Taszkun I.

1 Wydrych J.

1 Zmuda A.

1 2015

1 2012

Wyniki wyszukiwania

Effect of HMB and 2-Ox administered during pregnancy on bone properties in primiparous and multiparous minks (Neovison vison)

Postnatal administration of 2-oxoglutaric acid improves articular and growth plate cartilages and bone tissue morphology in pigs prenatally treated with dexamethasone