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Role of NAD[P]H: quinone oxidoreductase [NQO1] in apoptosis induction by aziridinylbenzoquinones RH1 and MeDZQ

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Nemeikaite-Ceniene A., Dringeliene A., Sarlauskas J., Cenas N.

Acta Biochimica Polonica

2005

tom 52

nr 4

We aimed to characterize the role of NAD(P)H : quinone oxidoreductase (NQO1) in apoptosis induction by antitumour quinones RH1 (2,5-diaziridinyl-3-hydroxymethyl-6-methyl-1,4-benzoquinone) and MeDZQ (2,5-dimethyl-3,6-diaziridinyl-1,4-benzoquinone). Digitonin-permeabilized FLK cells catalyzed NADPH-dependent single- and two-electron reduction of RH1 and MeDZQ. At equitoxic concentrations, RH1 and MeDZQ induced apoptosis more efficiently than the nonalkylating duroquinone or H2O2. The antioxidant N,N'-diphenyl-p-phenylene diamine, desferrioxamine, and the inhibitor of NQO1 dicumarol, protected against apoptosis induction by all compounds investigated, but to a different extent. The results of multiparameter regression analysis indicate that RH1 and MeDZQ most likely induce apoptosis via NQO1-linked formation of alkylating species but not via NQO1-linked redox cycling.

Ograniczanie wyników

1 Acta Biochimica Polonica

1 Cenas N.

1 Dringeliene A.

1 Nemeikaite-Ceniene A.

1 Sarlauskas J.

1 2005

Wyniki wyszukiwania

Role of NAD[P]H: quinone oxidoreductase [NQO1] in apoptosis induction by aziridinylbenzoquinones RH1 and MeDZQ