Wyniki wyszukiwania

Wyszukiwano:
w słowach kluczowych: 2'-deoxyisoguanosine

Sortuj według:

Ogranicz wyniki do:

Synthesis and application of novel nucleoside phosphonates and phosphoramidites modified at the base moiety

100%

Seela F., Chen Y., Melenewski A., Rosemeyer H., Wei C.

Acta Biochimica Polonica

1996

tom 43

nr 1

The H-phosphonates and phosphoramidites of 2'-deoxyisoguanosine, 2'-deoxy- isoinosine, 5-aza-7-deaza-2'-deoxyguanosine, and \:1-methyl-2'-deoxyformycin A were prepared. The diphenylcarbamoyl group was chosen for the 2-O-protection of 2'-deoxyisoinosine and 2'-deoxyisoguanosine, and dimethylaminoalkylidene groups were used to block the amino function of the various monomers. The synthesis of isoguanine oligonucleotides was found to be much more efficient using the 2-O-protected building blocks compared to those without oxygen protection. Oligodeoxynucleotides containing 2-deoxyisoguanosine and 2'-deoxycytidine form parallel duplex structures. The self-complementary duplex containing 5-aza-7-deaza- 2'-deoxyguanosine and 2'-deoxycytidine forms a stable duplex in acidic solution (pH = 5.0) while it is destabilized under neutral conditions.

Ograniczanie wyników

1 Acta Biochimica Polonica

1 Chen Y.

1 Melenewski A.

1 Rosemeyer H.

1 Seela F.

1 Wei C.

1 1996

Wyniki wyszukiwania

Synthesis and application of novel nucleoside phosphonates and phosphoramidites modified at the base moiety