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Effect of 10-day treatment with Padma 28 on some biochemical parameters in rats acutely intoxicated with cadmium chloride

100%

Jagiello-Wojtowicz E., Jeleniewicz K., Chodkowska A., Saj E.

Herba Polonica

2004

tom 50

nr 2

The aim of the study was to investigate the effect of 10-day treatment (i.p.) with Padma 28 on the levels of a-fetoprotein and ß2-microglobulin and the activities of aminotransferases ALT and AST in the serum of cadmium-poisoned rats (dose of 0.36 mg/kg i.p.). It was found that acute intoxication with cadmium chloride significantly enhanced AFP and ß2-microglobulin levels and did not affect the activity of ALT and AST in the serum of rats in comparison with the control group. Padma 28 administrated for 10-days only in the dose of 1 mg/kg significantly decreased AFP and in the doses of 0.1 and 1 mg/kg increased ß2-microglobulin levels while it did not affect the activity of ALT and AST in the serum of cadmium-poisoned rats. 10-day treatment with Padma 28 has been found to increase nephrotoxic effects of cadmium in rats acutely intoxicated with this metal.

Effect of 10-day treatment with Padma 28 on the serum alpha-fetoprotein and beta2-microglobulin levels in rats pretreated with subacute intoxication of cadmium chloride

84%

Jagiello-Wojtowicz E., Jeleniewicz K., Chodkowska A.

Herba Polonica

2002

tom 48

nr 4

The aim of the study was to investigate the effect of 10-day treatment with Padma 28 on the levels of α-fetoprotein (AFP) and β₂-microglobulin in the serum of cadmium-poisoned rats. It was found that subacute intoxication with cadmium chloride significantly enhanced AFP and β₂-micro-globulin levels in the serum of cadmium-poisoned rats in comparison with the group receiving cadmium only. The data presented here indicated protective action of Padma 28 in cadmium-poisoned rats.

Ograniczanie wyników

2 Herba Polonica

2 Chodkowska A.

2 Jagiello-Wojtowicz E.

2 Jeleniewicz K.

1 Saj E.

1 2004

1 2002

Wyniki wyszukiwania

Effect of 10-day treatment with Padma 28 on some biochemical parameters in rats acutely intoxicated with cadmium chloride

Effect of 10-day treatment with Padma 28 on the serum alpha-fetoprotein and beta2-microglobulin levels in rats pretreated with subacute intoxication of cadmium chloride