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Evaluation of the immunomodulatory activity of four compounds exerting antimutagenic effects on human lymphocytes in vitro

100%

Gasiorowski K., Brokus B., Tabaka H.

Cellular and Molecular Biology Letters

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2000

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tom 05

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nr 4

469-481

Four compounds previously described as antimutagenic for human lymphocytes in vitro were tested on their immunomodulatory activity in lymphocyte cultures. The standard immunocytochemical methods were applied for microscopic examination of the percentual representation of the main lymphocyte subpopulation. The results imply that all of the tested compounds exhibited significant immunomodulatory effect, with that of fluphenazine being the strongest, whereas that of todralazine is the weakest. Two of the tested compounds: anthocyanins from Aronia melanocarpa fruit, and alkylresorcinols from cereal grains, also exhibited a distinct immunomodulatory activity, and it deserves adequate attention as an activity exerted by natural products, commonly present in regular human diet. The analysis of the proliferating cell fraction, and the estimation of the cell proliferation rate suggest that the effect of the tested compounds might depend on an increase in the number of lymphocytes which expressed their differentiation antigens on the cell membranes.

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In vitro immunomodulatory activity of the methanolic-water extract from Chinese wolfberry fruits [Lycium chinensis Mill.]

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Gasiorowski K., Tabaka H., Dzialo E., Noculak-Palczewska A., Lamer-Zarawska E.

Herba Polonica

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2003

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tom 49

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nr 3-4

The influence of methanolic-water extract from Chinese wolfberry fruits (Lycium chinensis Mill.) on human lymphocyte proliferation and on frequencies of the main subpopulation of T lymphocytes after 72 h culture was studied. The extract mildly decreased frequency of proliferating lymphocytes while it markedly increased the CD4/CD8 ratio; the last effect stems from its activity on elevation of CD4+ cells number and lowering of CD8+ cell numbers. Impact of the extract on free radical generation by granulocyte samples in vitro included an increase of free radical level in non-stimulated granulocytes and a decrease of free radicals in granulocyte samples stimulated with the standard activator (PMA). The results documented a complex in vitro immunomodulatory action of the extract.

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Chemical characterisation of methanolic-water extracts from the fruit of acclimated Lycium chinense Mill.

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Noculak-Palczewska A., Matkowski A., Gasiorowski K., Tabaka H., Oszmianski J., Lamer-Zarawska E.

Herba Polonica

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2004

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tom 50

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nr 1

Methanolic-water extracts of wolfberry fruit (Lycii Fructus) harvested from plants cultivated in Poland have been analysed chemically to reveal compounds responsible for the biological activity of the crude drug. The potential for the scavenging of free radicals has been tested by means of a DPPH spectrophotometric assay. In the extracts several compounds with potential antioxidant properties have been detected: L-ascorbic acid, tocopherols (a, ß and y), ß-carotene, as well as phenolic acids (gallic, protocatechic, caffeic, chlorogenic, neochlorogenic). A considerable free-radical scavenging activity was confirmed by a DPPH assay, with EC50 of the extract being 24.08 mg/l.

Ograniczanie wyników

2 Herba Polonica

1 Cellular and Molecular Biology Letters

3 Gasiorowski K.

3 Tabaka H.

2 Lamer-Zarawska E.

2 Noculak-Palczewska A.

1 Brokus B.

1 Dzialo E.

1 Matkowski A.

1 Oszmianski J.

1 2004

1 2003

1 2000

Evaluation of the immunomodulatory activity of four compounds exerting antimutagenic effects on human lymphocytes in vitro

In vitro immunomodulatory activity of the methanolic-water extract from Chinese wolfberry fruits [Lycium chinensis Mill.]

Chemical characterisation of methanolic-water extracts from the fruit of acclimated Lycium chinense Mill.