Wyniki wyszukiwania

1

Artykuł dostępny w postaci pełnego tekstu - kliknij by otworzyć plik

Cathelicidin LL-37: LPS-neutralizing, pleiotropic peptide

100%

Golec M.

Annals of Agricultural and Environmental Medicine

|

2007

|

tom 14

|

nr 1

Human organism, constantly exposed to a large variety of pathogenic microorganisms and their products, such as lipopolysaccharide (LPS), developed innate immunity as a fi rst line of defence. One of the compartments of our organism well equipped with these defence mechanisms is the respiratory system. The cells lining the airways respond to the presence of virulent microorganisms by producing natural antimicrobial peptides, including the only member of the cathelicidins family found to date in humans, peptide LL-37. LL-37 is a small peptide of 37 amino acid residues. The peptide, in addition to its bactericidal effect, plays numerous roles in infl ammatory and tissue remodelling processes. It stimulates angiogenesis, induces proliferation of lung epithelial cells, accelerates wound closure of the airway epithelium, and provokes cytokine release (e.g. IL-8) and cell migration. LL-37 is also able to neutralize LPS, a heteropolymer associated with organic dust, produced by Gram-negative bacteria. LPS (commonly referred to as endotoxin) plays an important role in pathogenesis of many respiratory diseases caused by organic dust, including organic dust toxic syndrome and chronic illnesses such as chronic obstructive pulmonary disease (COPD), asthma or allergic alveolitis (hypersensitivity pneumonitis). LPS is a strong pro-infl ammatory stimulus, inducing in respiratory airways expression of antimicrobial peptides, including LL-37, which is in turn a potent LPS-neutralizing factor. The article discusses the complex interplay between endotoxin and the LPS-neutralizing, pleiotropic peptide LL-37 in pathogenic mechanisms of lung diseases, with regard to closer perspectives of using LL-37 and its derivatives as therapeutic agents.

2

Zanieczyszczenie srodowiska metalami ciezkimi wokol elektrowni w Kozienicach

63%

Krolak E., Golec M.

Ochrona Powietrza i Problemy Odpadów

|

1999

|

tom 33

|

nr 4

135-139

3

A novel inhalation challenge set to study animal model of allergic alveolitis

51%

Golec M., Skorska C., Lemieszek M., Dutkiewicz J.

Annals of Agricultural and Environmental Medicine

|

2009

|

tom 16

|

nr 1

173-175

4

Immunologic reactivity to work-related airborne allergens in people occupationally exposed to dust from herbs

51%

Golec M., Skorska C., Mackiewicz B., Dutkiewicz J.

Annals of Agricultural and Environmental Medicine

|

2004

|

tom 11

|

nr 1

A group of 150 people occupationally exposed to dust from herbs were examined. The examined group consisted of 47 thyme farmers, 32 chamomile farmers, 31 sage farmers and 40 workers of herbs processing industry. As a reference group, 50 urban dwellers, not exposed to any kind of organic dust, were examined. Skin prick tests and precipitin tests were conducted with, respectively, 4 and 11 microbial antigens associated with organic dust. Both skin and precipitin tests were also conducted with herbal extracts of chamomile and sage. Precipitin tests were carried out with sera not concentrated and sera 3-fold concentrated. Tests for inhibition of leukocyte migration (MIF) were also conducted with 4 microbial antigens. People occupationally exposed to dust from herbs showed a higher frequency of positive skin reactions to microbial antigens compared to the reference group. The results of precipitin test also revealed greater reactivity to the environmental microbial antigens in the examined group, compared to the reference group. The highest frequency of positive results was noted with the antigen of Pantoea agglomerans (30.6% with sera not concentrated and 48.3% with sera 3-fold concentrated) - the difference compared to the reference group (12.0%) was highly significant (p < 0.01). The frequencies of positive results of MIF test in the examined group were high with all antigens tested: Arthrobacter globiformis (12.6%), Pantoea agglomerans (11.1%), Saccharopolyspora rectivirgula (17.0%), Aspergillus fumigatus (13.3%), and, compared to the reference group with no positive result for any antigen, all the differences were significant (p < 0.05). In conclusion, the frequency of positive allergological reactions to airborne microorganisms was high in people occupationally exposed to dust from herbs and suggests a potential role of microbial allergens in the pathogenesis of work-related health disorders among herb workers. The risk of sensitization seems to be greatest among thyme farmers, who showed the highest positive response. The results confirmed the particular allergenic importance of Gram-negative bacterium Pantoea agglomerans.

5

Pantoea agglomerans: a mysterious bacterium of evil and good. Part IV. Beneficial effects

45%

Dutkiewicz J., Mackiewicz B., Lemieszek M. K., Golec M., Milanowski J.

Annals of Agricultural and Environmental Medicine

|

2016

|

tom 23

|

nr 2

6

Pantoea agglomerans: a mysterious bacterium of evil and good. Part III. Deleterious effects: infections of humans, animals and plants

45%

Dutkiewicz J., Mackiewicz B., Lemieszek M. K., Golec M., Milanowski J.

Annals of Agricultural and Environmental Medicine

|

2016

|

tom 23

|

nr 2

7

Pantoea agglomerans: a mysterious bacterium of evil and good. Part I. Deleterious effects: Dust-borne endotoxins and allergens - focus on cotton dust

45%

Dutkiewicz J., Mackiewicz B., Lemieszek M. K., Golec M., Milanowski J.

Annals of Agricultural and Environmental Medicine

|

2015

|

tom 22

|

nr 4

8

Health effects of exposure to herb dust in valerian growing farmers

45%

Skorska C., Golec M., Mackiewicz B., Gora A., Dutkiewicz J.

Annals of Agricultural and Environmental Medicine

|

2005

|

tom 12

|

nr 2

247-252

9

Cathelicidin influence on pathological activation of Wnt pathway in murine model of hypersensitivity pneumonitis

45%

Lemieszek M. K., Golec M., Zwolinski J., Dutkiewicz J., Milanowski J.

Annals of Agricultural and Environmental Medicine

|

2022

|

tom 29

|

nr 3

10

Respiratory effects of exposure to dust from herbs

45%

Golec M., Skorska C., Mackiewicz B., Gora A., Dutkiewicz J.

Annals of Agricultural and Environmental Medicine

|

2005

|

tom 12

|

nr 1

A group of 150 people occupationally exposed to dust from herbs were examined. As a reference group, 50 urban dwellers, not exposed to any kind of organic dust were examined. People were subjected to routine physical examination and to lung function examinations with the LUNGTEST 500 spirometer (MES, Krakow, Poland). The spirometric values of the forced expiratory volume in one second (FEV1), vital capacity (VC) and FEV1/VC were recorded before and after work. Physical chest examination revealed pathological crepitations in 10 people (6.7%). The mean baseline spirometric values in the study and reference groups did not show significant differences compared to the normal values. In the herb workers exposed to organic dust the post-shift decrease of all analysed spirometric values was noted. The post-shift decrease of some spirometric values (VC, VC% of normal values) was highly significant (p<0.01). There was evidenced of a significant positive correlation between the age of examined people and decrease of VC and FEV1 values. In 12 exposed workers the decrease of FEV1 or FEV1% of normal values higher than 15% was noted. 50% of these workers cultivated thyme (Thymus vulgaris L.). This may suggest that dust from herbs, especially thyme dust, may cause acute airway obstruction. In the group showing significant decrease of FEV1/FEV1% of normal values (>15%) the frequency of reported respiratory work-related symptoms (83.3%) was higher than in the rest of exposed group (61.5%). In conclusion, occupational exposure to dust from herbs may cause harmful effects on the respiratory system among herb processing workers. This indicates the need for use of prophylactic measures in this professional group, the more so as number of people occupationally exposed to dust from herbs is growing.

11

Pantoea agglomerans: a mysterious bacterium of evil and good. Part II - Deleterious effects: Dustborne endotoxins and allergens - focus on grain dust, other agricultural dusts and wood dust

39%

Dutkiewicz J., Mackiewicz B., Lemieszek M. K., Golec M., Skorska C., Gora-Florek A., Milanowski J.

Annals of Agricultural and Environmental Medicine

|

2016

|

tom 23

|

nr 1

12

Exposure to airborne microorganisms and endotoxin in herb processing plant

39%

Dutkiewicz J., Krysinska-Traczyk E., Skorska C., Sitkowska J., Prazmo Z., Golec M.

Annals of Agricultural and Environmental Medicine

|

2001

|

tom 08

|

nr 2

13

Health effects of exposure to organic dust in workers of a modern hatchery

39%

Skorska C., Mackiewicz B., Golec M., Cholewa G., Chmielowiec-Korzeniowska A., Dutkiewicz J.

Annals of Agricultural and Environmental Medicine

|

2007

|

tom 14

|

nr 2

The aim of the presented study was to determine the health status of workers occupationally exposed to moderate amounts of organic dust, employed in a modern hatchery with an effi cient ventilation system. A group of 32 hatchery workers was examined. As a reference group, 50 urban dwellers not exposed to any kind of organic dust were examined. All people were interviewed for the presence of work-related symptoms and subjected to physical and spirometric examinations. Blood sera were examined for the presence of precipitins against 13 antigens associated with organic dust, and for the presence of total and chicken-specifi c No signifi cant differences were found between the spirometric values in the group of hatchery workers and the reference group. Positive precipitin reactions were noted mostly with the antigens of Gram-negative bacteria associated with organic dust. The frequencies of positive reactions to antigens of Escherichia coli and Acinetobacter baumannii in hatchery workers were signifi cantly greater compared to the reference group (p<0.05). Precipitin reactions to Gram-positive non-branching bacteria, actinomycetes, fungi and bird protein, were rare or absent. The mean concentration of total IgE in sera of hatchery workers was nearly 3 times greater compared to the reference group, and the difference proved to be statistically signifi cant (p<0.05). No specifi c IgE antibodies against chicken feathers were detected in the blood of hatchery workers and referents. In conclusion, the examined hatchery workers showed a moderate frequency of work-related symptoms, no decline in lung function and low reactivity to most microbial and bird protein allergens. These results suggest that the effects of exposure to organic dust in workers of modern hatcheries with an effi cient ventilation system are less compared to the workers of poultry farms, such as broiler or egg laying houses.

14

Exposure to bioaerosols in the selected agricultural facilities of the Ukraine and Poland - a review

33%

Tsapko V. G., Chudnovets A. J., Sterenbogen M. J., Papach V. V., Dutkiewicz J., Skorska C., Krysinska-Traczyk E., Golec M.

Annals of Agricultural and Environmental Medicine

|

2011

|

tom 18

|

nr 1

15

Response of herb processing workers to work-related airborne allergens

33%

Dutkiewicz J., Skorska C., Milanowski J., Mackiewicz B., Krysinska-Traczyk E., Dutkiewicz E., Matuszyk A., Sitkowska J., Golec M.

Annals of Agricultural and Environmental Medicine

|

2001

|

tom 08

|

nr 2

16

Occupational exposure to organic dust, microorganisms, endotoxin and peptidoglycan among plants processing workers in Poland

27%

Gora A., Mackiewicz B., Krawczyk P., Golec M., Skorska C., Sitkowska J., Cholewa G., Larsson L., Jarosz M., Wojcik-Fatla A., Dutkiewicz J.

Annals of Agricultural and Environmental Medicine

|

2009

|

tom 16

|

nr 1

143-150

17

Cathelicidin LL-37, granzymes, TGF-beta1 and cytokines levels in induced sputum from farmers with and without COPD

27%

Golec M., Reichel C., Mackiewicz B., Skorska C., Curzytek K., Lemieszek M., Dutkiewicz J., Gora A., Ziesche R., Boltuc J., Sodolska K., Milanowski J., Spiewak R.

Annals of Agricultural and Environmental Medicine

|

2009

|

tom 16

|

nr 2

289-297

18

Mouse model of hypersensitivity pneumonitis after inhalation exposure to different microbial antigens associated with organic dusts

27%

Lemieszek M., Chilosi M., Golec M., Skorska C., Huaux F., Yakoub Y., Pastena C., Daniele I., Cholewa G., Sitkowska J., Lisowska W., Zwolinski J., Milanowski J., Mackiewicz B., Gora A., Dutkiewicz J.

Annals of Agricultural and Environmental Medicine

|

2011

|

tom 18

|

nr 1

19

Age influence on mice lung tissue response to Aspergillus fumigatus chronic exposure

27%

Lemieszek M. K., Dutkiewicz J., Golec M., Chilosi M., Skorska C., Huaux F., Pastena C., Pedica F., Sitkowska J., Lisowska W., Cholewa G., Zwolinski J., Mackiewicz B., Gora-Florek A., Ziesche R., Milanowski J.

Annals of Agricultural and Environmental Medicine

|

2015

|

tom 22

|

nr 1

Ograniczanie wyników

Cathelicidin LL-37: LPS-neutralizing, pleiotropic peptide

Zanieczyszczenie srodowiska metalami ciezkimi wokol elektrowni w Kozienicach

A novel inhalation challenge set to study animal model of allergic alveolitis

Immunologic reactivity to work-related airborne allergens in people occupationally exposed to dust from herbs

Pantoea agglomerans: a mysterious bacterium of evil and good. Part IV. Beneficial effects

Pantoea agglomerans: a mysterious bacterium of evil and good. Part III. Deleterious effects: infections of humans, animals and plants

Pantoea agglomerans: a mysterious bacterium of evil and good. Part I. Deleterious effects: Dust-borne endotoxins and allergens - focus on cotton dust

Health effects of exposure to herb dust in valerian growing farmers

Cathelicidin influence on pathological activation of Wnt pathway in murine model of hypersensitivity pneumonitis

Respiratory effects of exposure to dust from herbs

Pantoea agglomerans: a mysterious bacterium of evil and good. Part II - Deleterious effects: Dustborne endotoxins and allergens - focus on grain dust, other agricultural dusts and wood dust

Exposure to airborne microorganisms and endotoxin in herb processing plant

Health effects of exposure to organic dust in workers of a modern hatchery

Exposure to bioaerosols in the selected agricultural facilities of the Ukraine and Poland - a review

Response of herb processing workers to work-related airborne allergens

Occupational exposure to organic dust, microorganisms, endotoxin and peptidoglycan among plants processing workers in Poland

Cathelicidin LL-37, granzymes, TGF-beta1 and cytokines levels in induced sputum from farmers with and without COPD

Mouse model of hypersensitivity pneumonitis after inhalation exposure to different microbial antigens associated with organic dusts

Age influence on mice lung tissue response to Aspergillus fumigatus chronic exposure