Fruiting bodies of oyster mushrooms was grown in medium containing wheat straw and stillage. Decoction used rye and potato. Growing medium inoculated homogenized myce- lium grown in liquid medium containing stillage. Yield of mushrooms in a medium containing rye decoction was 15,5%. In medium containing potato decoction was 13,3%. Yield was comparable to that achieved during the traditional growing oyster mushrmms. The content of heavy metals in the fruiting bodies was lower than permitted by applicable standards.