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Psychoactive plants used in designer drugs as a threat to public health

100%

Rondzisty A., Dziekan K., Kowalska A.

Herba Polonica

2015

tom 61

nr 2

Based on epidemiologic surveys conducted in 2007–2013, an increase in the consumption of psychoactive substances has been observed. This growth is noticeable in Europe and in Poland. With the ‘designer drugs’ launch on the market, which ingredients were not placed on the list of controlled substances in the Misuse of Drugs Act, a rise in the number and diversity of psychoactive agents and mixtures was noticed, used to achieve a different state of mind. Thus, the threat to the health and lives of people who use them has grown. In this paper, the authors describe the phenomenon of the use of plant psychoactive substances, paying attention to young people who experiment with new narcotics. This article also discusses the mode of action and side effects of plant materials proscribed under the Misuse of Drugs Act in Poland.

Kamica moczowa

100%

Kleczkowski M., Klucinski W., Dziekan K., Wojewoda L.

Wiadomości Rolnicze. Ośrodek Doradztwa Rolniczego w Szepietowie

1997

nr 09

Impact of Panax ginseng and Ginkgo biloba extracts on expression level of transcriptional factors and xenobiotic-metabolizing cytochrome P450 enzymes

64%

Bogacz A., Karasiewicz M., Dziekan K., Procyk D., Gorska-Paukszta M., Kowalska A., Mikolajczak P. L., Ozarowski M., Czerny B.

Herba Polonica

2016

tom 62

nr 1

Introduction: Despite widespread use of Panax ginseng and Ginkgo biloba, the data on the safety as well as herb-drug interactions are very limited. Therefore, we postulate that P. ginseng and G. biloba may modulate the activity and content of cytochrome P450 isozymes involved in the biotransformation of diverse xenobiotic substances. Objective: The aim of our study was to determine the influence of herbal remedies on the expression level of CYP enzymes and transcriptional factors. Methods: Male Wistar rats were given standardized Panax ginseng (30 mg/kg p.o.) or standardized Ginkgo biloba (200 mg/kg p.o.) for 3 and 10 days. The expression in liver tissue was analyzed by realtime PCR method. Results: Our results showed a decrease of CYP3A1 (homologue to human CYP3A4) mRNA level after P. ginseng extract treatment. The CYP2C6 (homologue to human CYP2C9) expression was also reduced. Additionally, after 10 days of the treatment with P. ginseng an increase of CYP1A1 (homologue to human CYP1A1) and CYP1A2 (homologue to human CYP1A2) expression was observed. Moreover, G. biloba extract also caused an increase of expression level for CYP1A1, CYP2C6, CYP3A1 and CYP3A2. Conclusion: Our findings suggest that herbal extracts can modulate the expression of transcriptional factors and CYP enzymes involved in xenobiotic metabolism and chemical carcinogenesis.

Ograniczanie wyników

2 Herba Polonica

1 Wiadomości Rolnicze. Ośrodek Doradztwa Rolniczego w Szepietowie

3 Dziekan K.

2 Kowalska A.

1 Bogacz A.

1 Czerny B.

1 Gorska-Paukszta M.

1 Karasiewicz M.

1 Kleczkowski M.

1 Klucinski W.

1 Mikolajczak P. L.

1 Ozarowski M.

1 Procyk D.

1 Rondzisty A.

1 Wojewoda L.

1 2016

1 2015

1 1997

Wyniki wyszukiwania

Psychoactive plants used in designer drugs as a threat to public health

Kamica moczowa

Impact of Panax ginseng and Ginkgo biloba extracts on expression level of transcriptional factors and xenobiotic-metabolizing cytochrome P450 enzymes