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Wykrywanie DNA Toxoplasma gondii w lozysku ludzkim metoda polimerazowej reakcji lancuchowej a ocena histopatologiczna lozyska w procesie rozpoznawania toksoplazmozy wrodzonej

100%

Nowakowska D., Golab E., Czichos E., Krekora M., Wilczynski J.

Wiadomości Parazytologiczne

2002

tom 48

nr 3

301-309

Detection of Toxoplasma gondii in human placenta by PCR and placental histologic findings. Since isolation of Toxoplasma gondii from human placenta strongly correlates with fetal infection, the aims of the study were: to detect fragments of T. gondii B1 gene in human placentae by PCR and to evaluate their pathology. 36 placentae included in three groups were obtained: group I (n = 7) from pregnancies with prenatal diagnosis of fetal toxoplasmosis; II (n = 17) from women with serologic features of primary infection during pregnancy; III (n&13) from pregnancies with fetal T. gondii infection based on clinical signs. T. gondii DNA was found in 2/4 samples from the I group and in 1/14 from the II group. Villitis was identified in 3/15 other placentae from the II group. In the III group we did not recognize neither T. gondii DNA nor villitis. We consider PCR and pathologic evaluations of placentae as the two complementary methods. PCR can be especially helpful in pregnancies not screened against T. gondii as positive result in placenta can confirm mother's primary infection.

Umbilical cord serum magnesium level and neonatal outcome in group of neonates at 30-34 gestational age

72%

Gulczynska E., Zylinska L., Kesiak M., Grodzicka A., Zjawiona A., Cyranowicz B., Krekora M., Talar T., Gadzinowski J.

Journal of Elementology

2007

tom 12

nr 1

Aim of study. To find correlation between the umbilical serum cord magnesium concentration in a group of newborns without antenatal exposition to magnesium sulphate and the neonatal outcome as well as to compare the neonatal outcome of babies with maternal magnesium sulphate treatment. Results. In a group of 82 newborns (31-34 GA; birth body weight <1500 g) the umbilical cord serum magnesium concentrations was assayed. Three subgroups of neonates were set apart: first group (N) with a normal magnesium level (n=28), the second group (n=19) with magnesium concentration <0.75 mmol/dl (D), and the third group (Mg) consisting of 35 newborn antenatally exposed to magnesium sulphate. These groups were similar (no statistical significances) in terms of birth body weight, gestational age, Apgar score and umbilical blood pH. Gradual decrease in magnesium concentration in relation to increase of gestational age was observed. In groups: D, N, Mg, gradual reduction of hospitalization time (p<0.05), risk of death, time of respiratory support, time of oxygen therapy, rate of bronchopulmonary dysplasia, periventricular leucomalation (p<0.05) were observed respectively. Likewise, a rate of serious neurological complication (IVH/ PVL) in group D was higher in comparison to groups N and Mg (although without statistical sig-nificances). Conclusion. Our results confirm that umbilical cord magnesium concentration in VLBW neonates have an influence on neonatal outcome. Although it is premature to recommend ordering maternal magnesium sulphate treatment to improve neonatal outcome, in our opinion the data presented here should at least induce magnesium concentration monitoring in pregnant women and magnesium deficiency correction.

Ograniczanie wyników

1 Journal of Elementology

1 Wiadomości Parazytologiczne

2 Krekora M.

1 Cyranowicz B.

1 Czichos E.

1 Gadzinowski J.

1 Golab E.

1 Grodzicka A.

1 Gulczynska E.

1 Kesiak M.

1 Nowakowska D.

1 Talar T.

1 Wilczynski J.

1 Zjawiona A.

1 Zylinska L.

1 2007

1 2002

Wyniki wyszukiwania

Wykrywanie DNA Toxoplasma gondii w lozysku ludzkim metoda polimerazowej reakcji lancuchowej a ocena histopatologiczna lozyska w procesie rozpoznawania toksoplazmozy wrodzonej

Umbilical cord serum magnesium level and neonatal outcome in group of neonates at 30-34 gestational age