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1

Diet supplements, resveratrol and protocatechuic acid, do not disturb wellness and liver morphology in rats

100%
Szumilo J., Fraczek M., Klepacz R., Szumilo M., Burdan F.
Medycyna Weterynaryjna
|
2015
|
tom 71
|
nr 05
The aim of the study was to evaluate the influence of a prolonged administration of two natural compounds – resveratrol (20 ppm) and protocatechuic acid (2000 ppm) – on the health status of Wistar rats. The animals were kept on supplemented diets for 7 and 24 weeks. Body weight was assessed weekly, and liver weight during autopsy. Liver morphology was evaluated histologically. The body weight in the 24th week, body weight gain (between the 1st and the 24th week of the experiment), and liver weight were significantly higher for the animals kept on the diet including resveratrol throughout the experiment than for those that had received this diet during the initial 7 weeks. However, differences in these parameters, as well as in the relative liver weight, between the control group and the groups exposed to both compounds were insignificant. Occasionally, mild, mostly reversible, microscopic hepatic changes (i.e., hydropic and fatty changes) were found, and these were slightly more common in the groups kept on supplemented diets. It seems that resveratrol and protocatechuic acid did not significantly disturb the wellness of rats, even after prolonged exposure.
2
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Influence of environment on residence and selected demographic and clinical parameters of preschool children with IgE-dependent asthma

86%
Bednarek A., Klepacz R., Surtel A., Mazur A., Saran T., Zarzycka D., Emeryk A.
Annals of Agricultural and Environmental Medicine
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2019
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tom 26
|
nr 3
3

Aktywnosc dehydrogenazy mleczanowej ludzkich erytrocytow w obecnosci wybranych inhibitorow dehydrogenazy alkoholowej

86%
Dudka J., Burdan F., Madej B., Tokarska E., Klepacz R., Korobowicz E.
Roczniki Państwowego Zakładu Higieny
|
2004
|
tom 55
|
nr 3
229-234
W pracy oceniono wpływ cymetydyny, EDTA, 4-metylopirazolu oraz etanolu i metanolu na aktywność dehydrogenazy mleczanowej. Badania przeprowadzono in vitro z enzymem otrzymanym z erytrocytów ludzkich.
4

Anatomical variances and dimensions of the superior orbital fissure and foramen ovale in adults

86%
Burdan F., Umlawska W., Dworzanski W., Klepacz R., Szumilo J., Staroslawska E., Drop A.
Folia Morphologica
|
2011
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tom 70
|
nr 4
The aim of the study was the retrospective morphological analysis of selected structures of the middle cranial fossa, i.e. foramen ovale and superior orbital fissure, in relation to the external head and cranial diameters in adults from the Lublin region (Poland). The study was performed on data collected during computed tomography examinations of 60 individuals (age 20–30 years), without any cranial or brain abnormalities. Based on the post-processing reconstructions, 3-dimensional views of the skull and head were obtained. The length and width of both structures, as well as thickness of the frontal, temporal, and occipital squamae, were measured. The morphology of the ovale foramina and superior orbital fissures were checked. The length and width of the skull and head were the only parameters that significantly differed between males and females. The thickness of the frontal and temporal squama was insignificantly lower in males than in females. Almond and oval shapes were the most typical for the foramen ovale. The superior orbital fissure was found as a wide form — with or without accessory spine originating from its lower margin or as a laterally narrowed form. The length and width of the foramen ovale were insignificantly higher in males than in females. The same results were found for the area of the right superior orbital fissure. The thickness of the frontal and occipital squamae influenced the thickness of the temporal squama. The analysed individuals had asymmetrical, oval, or almond-shape ovale foramina. Unlike the seldom visible laterally narrowed form of the superior orbital fissure, a wide form with or without accessory spine was the most commonly observed. The diameters of both superior orbital fissures and ovale foramina indicated the asymmetry of the neurocranium. (Folia Morphol 2011; 70, 4: 263–271)
5

Expression of syndecan-1 and cathepsins D and K in advanced esophageal squamous cell carcinoma

86%
Szumilo J., Burdan F., Zinkiewicz K., Dudka J., Klepacz R., Dabrowski A., Korobowicz E.
Folia Histochemica et Cytobiologica
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2009
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tom 47
|
nr 4
6

Unusual interleukin-1 and -6 expression in fetal cartilage is associated with placental abnormalities

86%
Burdan F., Szumilo J., Korobowicz-Markiewicz A., Dyndor K., Szumilo M., Klepacz R.
Folia Histochemica et Cytobiologica
|
2010
|
tom 48
|
nr 1
30-36
7

Association of maternal pancreatic function and foetal growth in rats treated with DFU, a selective cyclooxygenase-2 inhibitor

86%
Burdan F., Szumilo J., Dudka J., Szumilo M., Korobowicz A., Chatterjee S., Klepacz R.
Folia Morphologica
|
2007
|
tom 66
|
nr 3
Constitutive (COX-1) and inducible (COX-2) cyclooxygenase isoforms have been detected in various mammalian tissues. Their activity is blocked by non-steroidal anti-inflammatory drugs that may induce various side reactions. The aim of the study was to evaluate the effects of DFU, a selective COX-2 inhibitor, on exocrine and endocrine pancreatic function and the immunoexpression of both COX isoforms in maternal and foetal rat pancreases. The compound was administered to pregnant Wistar rats once daily from the 8th to the 21st day of gestation. Glucose level and amylase activity were determined in the maternal sera. Maternal and foetal pancreases were examined histologically. Immunoexpression of COX-1 and COX-2 was also evaluated. Both biochemical parameters, as well as the histological structure of the pancreas were undisturbed in the dams and their foetuses. The maternal glucose level was found to be an important factor for foetal growth. Strong cytoplasmic COX-1 immunostaining was observed in acinar secretory cells, whereas in islets the immune reaction was weak. Endocrine cells also revealed strong cytoplasmic COX-2 staining in the maternal and foetal pancreases. Acinar cells exhibited nuclear reaction, which was strong in the foetal but weak in the maternal pancreases. No differences in COX immunoexpression were found between the DFU-exposed and the control groups in either mothers or foetuses. It should be stressed that DFU administered throughout mid and late pregnancy in rats did not change maternal or foetal pancreatic morphology or immunoexpression of either of the main COX isoforms in the organ.
8

Morphology of the foramen magnum in young Eastern European adults

72%
Burdan F., Szumilo J., Walocha J., Klepacz L., Madej B., Dworzanski W., Klepacz R., Dworzanska A., Czekajska-Chehab E., Drop A.
Folia Morphologica
|
2012
|
tom 71
|
nr 4
Background: The foramen magnum is an important anatomical opening in the base of the skull through which the posterior cranial fossa communicates with the vertebral canal. It is also related to a number of pathological conditions including Chiari malformations, various tumours, and occipital dysplasias. The aim of the study was to evaluate the morphology of the foramen magnum in adult individuals in relation to sex. Material and methods: The morphology of the foramen magnum was evaluated using 3D computer tomography images in 313 individuals (142 male, 171 female) aged 20–30 years. Results: The mean values of the foramen length (37.06 ± 3.07 vs. 35.47 ± 2.60 mm), breadth (32.98 ± 2.78 vs. 30.95 ± 2.71 mm) and area (877.40 ± 131.64 vs. 781.57 ± 93.74 mm²) were significantly higher in males than in females. A significant, positive correlation was found between foramen length and breadth. Significant correlations were reported for breadth and area of the foramen magnum and corresponding external cranial diameters in females. Round as well as longitudinal and horizontal oval-like types of the foramen shape were established according to the breadth/length index of the structure. All the cranial and foramen measurements were significantly higher in individuals with round-like type of the foramen magnum. Conclusions: There was a sexual dimorphism of the foramen magnum among the examined individuals. It was related mainly to its linear diameters and area, not to the shape. Unlike males, female skulls had higher correlation between the examined parameters of the foramen and proper external cranial measurements, which indicates more homogeneous growth in girls. (Folia Morphol 2012; 71, 4: 205–216)
9

Early postnatal development of the lumbar vertebrae in male Wistar rats: double staining and digital radiological studies

72%
Burdon F., Blaszczak-Szalak M., Rozylo-Kalinowska I., Klepacz R., Dworzanski W., Rozylo T. K., Dudka J., Szumilo J.
Folia Morphologica
|
2016
|
tom 75
|
nr 1
The aim of the study was to evaluate the physiological developmental changes of male rats’ lumbar vertebrae during the first 22 days after birth. Morphology and mineralisation of lumbar vertebrae were evaluated using double-staining and digital radiography system, which allowed vertebral width and optical density to be determined. Pup weight, crown-rump length, body mass index and vertebral width increased during postnatal period and significantly correlated with their age. Bone mineralisation, as measured by optical density, did not show any significant differences. The complete fusion of the primary ossification centres had a cranio-caudal direction and started on day 19 after parturition but was incomplete by day 22. It could be concluded that, unlike significant age-related increase of vertebral size, mineralisation was only slightly elevated during evaluated postnatal period. The method described is supplementary to alizarin red S staining as it provides both qualitative and quantitative data on mineralisation in a similar manner to micro computed tomography but does not allow 3 dimensional and microarchitecture examination. (Folia Morphol 2016; 75, 1: 1–13)
10

Immunoexpression of constitutive and inducible cyclooxygenase isoforms in distinguishing and accessory structures of synovial joints in rat foetuses

72%
Burdan F., Szumilo J., Dworzanski W., Szumilo M., Podlodowska J., Dyndor K., Madej B., Dworzanski J., Klepacz R.
Folia Morphologica
|
2009
|
tom 68
|
nr 2
Joint formation is a developmental process regulated by various factors including bone morphogenetic proteins, transforming and growth factors, etc. Recently, a high expression of cyclooxygenase (COX) isoforms in the foetal cartilaginous elements was also revealed. On the other hand, various joint and skeletal abnormalities were seen in laboratory animal and human offspring, exposed in utero to several COX inhibitors. Immunoexpression of constitutive (COX-1) and inducible (COX-2) cyclooxygenase isoforms was evaluated in various articular structures of untreated and unfamiliar 21-day-old male rat foetuses. Both COX isoforms were detected in the articular cartilage and joint capsule, as well as in the intra-articular disc of the temporomandibular joint and meniscus of the knee joint. COX-1 immunostaining was revealed in the anterior and posterior cruciate ligament of the knee joint and the labrum of the hip and shoulder, whereas COX-2 immunoreactivity in those structures was not found. It could be concluded that both constitutive and inducible COX isoforms are physiologically expressed in various structures of synovial joints in rat foetuses at the end of prenatal development. (Folia Morphol 2009; 68, 2: 59–64)
11

Morphology and physiology of the epiphyseal growth plate

59%
Burdan F., Szumilo J., Korobowicz A., Farooquee R., Patel S., Patel A., Dave A., Szumilo M., Solecki M., Klepacz R., Dudka J.
Folia Histochemica et Cytobiologica
|
2009
|
tom 47
|
nr 1
5-16
12

Morphological studies in modern teratological investigations

59%
Burdan F., Szumilo J., Dudka J., Klepacz R., Blaszczak M., Solecki M., Korobowicz A., Chalas A., Klepacki J., Palczak M., Zuchnik-Wrona A., Hadala-Kis A., Urbanowicz Z., Wojtowicz Z.
Folia Morphologica
|
2005
|
tom 64
|
nr 1
1-8
Despite the variety of modern molecular techniques available, examination of foetal anatomy is still a fundamental part of teratological studies in evaluating the developmental toxicity of xenobiotics or other non-chemical factors. The article presents contemporary methods of embryotoxicity and foetotoxicity assessment. A single alizarin red S and double alcian blue followed by alizarin red S staining, as well as various methods of soft tissue examination are discussed.
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