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1

Antiviral activities of Zn2plus ions for viral prevention, replication, capsid protein in intracellular proliferation of viruses

100%
Ishida T.
World Scientific News
|
2018
|
tom 97
2

Antiviral activities of Cu2plus ions in viral prevention, replication, RNA degradation, and for antiviral efficacies of lytic virus, ROS-mediated virus, copper chelation

100%
Ishida T.
World Scientific News
|
2018
|
tom 99
3
Artykuł dostępny w postaci pełnego tekstu - kliknij by otworzyć plik
Content available

Anticancer activities of ferrous and ferric ions in progression, proliferation, angiogenesis, invasion and metastasis against cancer and tumor cells

100%
Ishida T.
World News of Natural Sciences
|
2018
|
tom 17
The process of ferroptotic death is characterized by the overwhelming, iron-depending accumulation of lethal lipid ROS. Unlike other forms of apoptotic and non-apoptotic death, this requirement for ROS accumulation appears to be universal. Redox cycling is a characteristic of transition metals such as iron (Ferritin Fe3+ ⇄ Ferrous Fe2+). Iron via the Fenton reaction can exacerbate the consequences of hydrogen peroxide (H2O2) production, leading to the generation of hydroxyl radicals. The superoxide ion can participate in regenerating ferrous iron that is required for the Fenton reaction. An excess of iron is toxic due to its ability to engage in redox cycling and promote free radical formation. Super oxide anion generation; O2 → ･O2 －. Hydrogen peroxide production; ･O2 － + 2H++ e- → H2O2. Haber-Weiss reaction; H2O2 + O2－ → ･OH + OH－ + O2. Fenton reaction; Fe2+ + H2O2 → Fe3+ + OH－ + ･OH. Reduction to Fe(Ⅱ); Fe3+ ＋ ･O2－ → Fe2+ + O2. Ferritin is stable in iron-rich conditions, whereas it is rapidly degraded under conditions of iron starvation and ferritin degradation can be led. New blood vessel formation in angiogenesis is fundamental to tumor growth, invasion, and metastatic dissemination. Iron deficiency will lead to the dysfunction of immune system, metabolic disorders, myasthenia and anemia, whereas, excess iron also damages several vital organs. Thus, iron is essential for multiple cell functions, but is also potentially deleterious reasons of its ability to generate free oxygen radicals, iron balance by continuously recycling and reusing cellular iron, storage in ferritin, and export through ferroportin protecting cells from free iron toxicity. However. the exact molecular mechanism involved on iron imbalance in development for tumor cells and the iron overload-mediated induction of apoptosis are required to be explored in future.
4
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Effects of inoculation with a commercial microbial inoculant Bacillus subtilis C-3102 mixture on rice and barley growth and its possible mechanism in the plant growth stimulatory effect

33%
Jamily A. S., Koyama Y., Win T. A., Toyota K., Chikamatsu S., Shirai T., Uesugi T., Murakami H., Ishida T., Yasuhara T.
Journal of Plant Protection Research
|
2019
|
tom 59
|
nr 2
The effects of a microbial inoculant (Thervelics®: a mixture of cells of Bacillus subtilis C-3102 and carrier materials) on rice (Oryza sativa cv. Milkyprincess) and barley (Hordeum vulgare cv. Sachiho Golden) were evaluated in four pot experiments. In the first and second experiments, the dry matter production of rice and barley increased significantly by 10–20% with the inoculation of the mixture at a rate of 107 cfu ⋅ g–1 soil compared with the non-inoculated control. In the third experiment, the growth promoting effects of the mixture, the autoclaved mixture and the carrier materials were compared. The dry mater production of rice grains was the highest in the mixture, and it was significantly higher in the three treatments than in the control, suggesting that the carrier materials may also have a plant growth promoting effect and the living cells might have an additional stimulatory effect. To confirm the efficacy of the living cells in the mixture, only B. subtilis C-3102 cells were used in the fourth experiment. In addition, to estimate the mechanisms in growth promotion by B. subtilis C-3102, three B. subtilis strains with similar or different properties in the production of indole-3-acetic acid (IAA), protease and siderophore and phosphatesolubilizing ability were used as reference strains. Only B. subtilis C-3102 significantly increased the dry matter production of rice grains and the soil protease activity was consistently higher in the soil inoculated with B. subtilis C-3102 throughout the growing period. These results indicate that the microbial inoculant including live B. subtilis C-3102 may have growth promoting effects on rice and barley.
5

The accelerated clearance on repeated injection of pegylated liposomes in rats: laboratory and histopathological study

33%
Ishida T., Maeda R., Ichihara M., Mukai Y., Motoki Y., Manabe Y., Irimura K., Kiwada H.
Cellular and Molecular Biology Letters
|
2002
|
tom 07
|
nr 2
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