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1

Biological membranes: From passive barrier to active structure – Example of bacterial membranes

100%
Hendrich A. B.
Current Topics in Biophysics. Supplement
|
2013
|
tom 36
|
nr 2A: Plenary lectures
2

Rola lipidow blony komorkowej w zjawisku opornosci wielolekowej i jego modulacji.

63%
Michalak K., Hendrich A. B.
Postępy Biochemii
|
2002
|
tom 48
|
nr 3
208-219
3

Interaction of metalloporphyrins with lipid bilayers, a calorimetric study

51%
Pamin K., Poltowicz J., Kielkowicz J., Hendrich A. B.
Current Topics in Biophysics
|
2011
|
tom 34
|
nr 1
4

Giant unilamellar vesicles - a perfect tool to visualize phase separation and lipid rafts in model systems

51%
Wesolowska O., Michalak K., Maniewska J., Hendrich A. B.
Acta Biochimica Polonica
|
2009
|
tom 56
|
nr 1
33-39
 Model systems such as black lipid membranes or conventional uni- or multilamellar liposomes are commonly used to study membrane properties and structure. However, the construction and dimensions of these models excluded their direct optical microscopic observation. Since the introduction of the simple method of liposome electroformation in alternating electric field giant unilamellar vesicles (GUVs) have become an important model imitating biological membranes. Due to the average diameter of GUVs reaching up to 100 µm, they can be easily observed under a fluorescent or confocal microscope provided that the appropriate fluorescent probe was incorporated into the lipid phase during vesicle formation. GUVs can be formed from different lipid mixtures and they are stable in a wide range of physical conditions such as pH, pressure or temperature. This mini-review presents information about the methods of GUV production and their usage. Particularly, the use of GUVs in studying lipid phase separation and the appearance and behavior of lipid domains (rafts) in membranes is discussed but also other examples of GUVs use in membrane research are given. The experience of the authors in setting up the GUV-forming equipment and production of GUVs is also presented.
5

Compounds that modulate multidrug resistance in cancer cells

51%
Michalak K., Hendrich A. B., Wesolowska O., Pola A.
Cellular and Molecular Biology Letters
|
2001
|
tom 06
|
nr 2A
362-368
6

The role of phenothiazine ring substitution structure in the interaction of phenothiazine derivatives with zwitterionic lipids

51%
Hendrich A. B., Wesolowska O., Motohashi N., Michalak K.
Cellular and Molecular Biology Letters
|
2001
|
tom 06
|
nr 2A
397
7

Phenothiazine maleates - putative MDR modifiers - decrease the fluidity of model phospatidylserine membranes

51%
Wesolowska O., Hendrich A. B., Motohashi N., Michalak K.
Cellular and Molecular Biology Letters
|
2001
|
tom 06
|
nr 2A
427
8

Thioridazine induces erythrocyte stomatocytosis due to interactions with negatively charged lipids

51%
Hendrich A. B., Lichacz K., Burek A., Michalak K.
Cellular and Molecular Biology Letters
|
2002
|
tom 07
|
nr 4
Despite the fact that thioridazine is used clinically as a neuroleptic drug, little is known about the molecular mechanisms underlying its biological effects, in particular about its interactions with membranes. In the present work we investigate the influence of thioridazine on model and cell membranes, using calorimetry, DPH fluorescence polarization measurements, studies of haemolysis and scanning electron microscopy. The experiments show that thioridazine interacts with lipid bilayers and intercalates into bilayer structure. We found that erythrocyte stomatocytosis induced by the drug might be related to preferential interaction of thioridazine with charged lipids.
9

Biochanin A similarly influences the fluidity of liposomes formed from charget and zwitterionic lipids

51%
Hendrich A. B., Zugaj J., Michalak K.
Cellular and Molecular Biology Letters
|
2002
|
tom 07
|
nr 2
10

A new phenothiazine derivative alters the fluidity and thermotropic behaviour of phosphatidylcholine model membranes

51%
Wesolowska O., Hendrich A. B., Motohashi N., Michalak K.
Cellular and Molecular Biology Letters
|
2002
|
tom 07
|
nr 2
11

Interaction of major phospholipids of erythrocyte membrane's inner leaflet [PS, PE] with phenothiazine methanesulfonylamides

51%
Wesolowska O., Hendrich A. B., Motohashi N., Michalak K.
Cellular and Molecular Biology Letters
|
2001
|
tom 06
|
nr 2
12

The interaction of thioridazine with model lipid bilayers and erythrocyte membranes

51%
Hendrich A. B., Lichacz K., Burek A., Michalak K.
Cellular and Molecular Biology Letters
|
2002
|
tom 07
|
nr Suppl.
13

The effect of poneratoxin on neuromuscular transmission in the rat diaphragm

51%
Hendrich A. B., Mozrzymas J. W., Konopinska D., Scuka M.
Cellular and Molecular Biology Letters
|
2002
|
tom 07
|
nr 2
The effect of the ant venom neuropeptide - poneratoxin (PoTX) - on neuromuscular transmission in rat diaphragm tissue was studied by means of intracellular recordings of spontaneous miniature endplate potentials (MEPPs) and of nerve evoked endplate potentials (EPPs). A 2 µM concentration of PoTX caused a pronounced but transient increase in MEPPs frequency. Moreover, within the first few minutes of PoTX administration, the area, rise time and half decay time of MEPPs gradually decreased, reaching steady values after 15-20 min. The alteration of the area, rise time and half decay time of EPPs after PoTX application was similar to that observed for MEPPs. We conclude that PoTX affects neuromuscular transmission in rat tissue, and suggest that PoTX could exert both pre- and postsynaptic effects.
14

Multidrug resistance reversal in cancer cells and in pathogenic microorganisms

45%
Michalak K., Hendrich A. B., Wesolowska O., Pola A., Lania-Pietrzak B.
Cellular and Molecular Biology Letters
|
2002
|
tom 07
|
nr Suppl.
15

Perturbation of the lipid phase of a membrane is not involved in the modulation of MRP1 transport activity by flavonoids

39%
Wesolowska O., Hendrich A. B., Lania-Pietrzak B., Wisniewski J., Molnar J., Ocsovszki I., Michalak K.
Cellular and Molecular Biology Letters
|
2009
|
tom 14
|
nr 2
199-221
The expression of transmembrane transporter multidrug resistance-associated protein 1 (MRP1) confers the multidrug-resistant phenotype (MDR) on cancer cells. Since the activity of the other MDR transporter, P-glycoprotein, is sensitive to membrane perturbation, we aimed to check whether the changes in lipid bilayer properties induced by flavones (apigenin, acacetin) and flavonols (morin, myricetin) were related to their MRP1 inhibitory activity. All the flavonoids inhibited the efflux of MRP1 fluorescent substrate from human erythrocytes and breast cancer cells. Morin was also found to stimulate the ATPase activity of erythrocyte ghosts. All flavonoids intercalated into phosphatidylcholine bilayers as judged by differential scanning calorimetry and fluorescence spectroscopy with the use of two carbocyanine dyes. The model of an intramembrane localization for flavones and flavonols was proposed. No clear relationship was found between the membrane-perturbing activity of flavonoids and their potency to inhibit MRP1. We concluded that mechanisms other than perturbation of the lipid phase of membranes were responsible for inhibition of MRP1 by the flavonoids.
16
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Evaluation of the prevalence and molecular characterization of Pneumocystis jirovecii in patients with a variety of respiratory diseases

33%
Sokulska M., Kicia M., Piesiak P., Matos O., Lobo M. L., Kopacz Z., Wesolowska M., Hendrich A. B.
Annals of Parasitology
|
2016
|
tom 62
|
nr Suppl.
17

Lipid membrane perturbation caused by some isoflavones and phenothiazines, and the activity of these compounds as inhibitors of multidrug resistance

33%
Michalak K., Hendrich A. B., Wesolowska O., Pola A., Lania-Pietrzak B., Motohashi N., Shirataki Y., Molnar J.
Cellular and Molecular Biology Letters
|
2002
|
tom 07
|
nr 2
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