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1

Zrównoważona turystyka miejska jako podstawa rewitalizacji miasta turystycznego w Wielkopolsce

100%
Kazmierczak B.
Teka Komisji Architektury, Urbanistyki i Studiów Krajobrazowych
|
2008
|
tom 04b
2

Brudzenski Park Krajobrazowy

100%
Kazmierczak B.
Kraska. Biuletyn Mazowieckiego Towarzystwa Ochrony Fauny
|
2004
|
nr 1-2[11]
42-46
3

Turystyka zrównoważona jako istotny czynnik aktywizacji małych miast

100%
Kazmierczak B.
Teka Komisji Architektury, Urbanistyki i Studiów Krajobrazowych
|
2011
|
tom 07
4

Tygrzyk paskowany Argiope bruennichi w Brudzenskim Parku Krajobrazowym

88%
Kazmierczak B.
Chrońmy Przyrodę Ojczystą
|
2001
|
tom 57
|
nr 1
103-105
5

Przyczynek do fauny drobnych ssaków Niziny Mazowieckiej: nowe stanowisko popielicy Glis glis (Linnaeus, 1766)

63%
Kazmierczak B., Kaliszewski I.
Przegląd Zoologiczny
|
1989
|
tom 33
|
nr 4
6

Stanowisko skrzypu olbrzymiego Equisetum maximum w wojewodztwie plockim

63%
Kaliszewski I., Kazmierczak B.
Chrońmy Przyrodę Ojczystą
|
1992
|
tom 48
|
nr 2
98-100
7

Program ochrony plomykowki na terenie Brudzenskiego i Gostyninsko-Wloclawskiego Parku Krajobrazowego

63%
Kaliszewski I., Kazmierczak B.
Kraska. Biuletyn Mazowieckiego Towarzystwa Ochrony Fauny
|
2001
|
nr 2[07]
8-9
8

Otwarta zagroda w powiecie gnieznienskim

63%
Marciniak M., Kazmierczak B.
Poradnik Gospodarski
|
2005
|
nr 10
47
9

Phytoseiid mites [Acari: Phytoseiidae] inhabiting coniferous trees in natural habitats in Poland

63%
Kazmierczak B., Lewandowski M.
Biological Letters
|
2006
|
tom 43
|
nr 2
10
Artykuł dostępny w postaci pełnego tekstu - kliknij by otworzyć plik
Content available

Kolonia legowa kormorana czarnego /Phalacrococax carbo/ pod Plockiem.

63%
Kazmierczak B., Kaliszewski I.
Kulon
|
1997
|
tom 02
|
nr 2
201-206
11

Dni Pola w powiecie gnieźnieńskim

63%
Kazmierczak B.
Poradnik Gospodarski
|
2016
|
nr 10
12

Wplyw zatrucia heroina na aktywnosc i ekspresje transferazy S-glutationowej w korze mozgowej czlowieka

51%
Gutowicz M., Kazmierczak B., Baranczyk-Kuzma A.
Bromatologia i Chemia Toksykologiczna
|
2006
|
tom 39
|
nr 4
377-381
13
Artykuł dostępny w postaci pełnego tekstu - kliknij by otworzyć plik
Content available

Analysis of water losses and failure frequency in an urban-rural water supply system

51%
Gwozdziej-Mazur J., Swietochowski K., Kazmierczak B.
Ekonomia i Środowisko
|
2018
|
nr 2[65]
14

Ekspresja transferazy S-glutationowej pi w transgenicznych mysich modelach neurodegeneracji

51%
Kazmierczak B., Usarek E., Kuzma-Kozakiewicz M., Baranczyk-Kuzma A.
Medycyna Weterynaryjna
|
2008
|
tom 64
|
nr 06
812-814
Glutathione S-transferase pi (GST pi) inactivates a large variety of toxic, electrophilic compounds. The substrates of GST pi include environmental toxins and intracellular reactive oxygen species, factors significant in the pathogenesis of neurodegenerative diseases. The aim of the present study was to investigate the expression of glutathione S-transferase pi in transgenic mouse models of neurodegeneration on both the mRNA and protein levels. Experiments were conducted on the frontal cortex of transgenic B6-C3H hybrids SOD1, Cra1 and SOD1/Cra1, aged 70 and 140 days. The SOD1 mice express a human SOD1ᴳ⁹³ᴬ mutation, the Cra1 strain carries mutation in the cytoplasmic dynein heavy chain 1 (Dnchc1), and the double heterozygote SOD1/Cra1 mice show a delayed disease progression as well as an increased lifespan compared with the SOD1 strain. A wild strain of mice were used as a control. The expression of GST pi mRNA in younger mice (age 70 days) was found to be similar in all studied groups of animals. In older (aged 140 days) controls and Cra1 mice the GST pi expression was at a similar level and it did not significantly differ from younger animals. In SOD1 and SOD1/Cra1 strains, the mRNA-GST pi expression was lower when compared to 140-day-old controls and the Cra1 strain. Moreover, it was significantly lower than in corresponding 70-day-old animals. A decrease in the GST pi expression on the mRNA level was accompanied by a decrease in the protein level. High and unchanged GST pi expression in the frontal cortex of Cra1 mice indicates that the antioxidant-detoxification system plays an important role in protection against neurodegeneration. A significant decrease of GST pi expression in the frontal cortex of SOD1 and SOD1/Cra1 mice at the symptomatic stage of the disease suggests that the expression of this enzyme is related more to the G93A mutation in the SOD1 gene than to the efficient axonal transport.
15

Differences in glutathione S-transferase pi expression in transgenic mice with symptoms of neurodegeneration

51%
Kazmierczak B., Kuzma-Kozakiewicz M., Usarek E., Baranczyk-Kuzma A.
Acta Biochimica Polonica
|
2011
|
tom 58
|
nr 4
Glutathione S-transferase pi (GST pi) is an enzyme involved in cell protection against toxic electrophiles and products of oxidative stress. GST pi expression was studied in transgenic mice hybrids (B6-C3H) with symptoms of neurodegeneration harboring SOD1G93A (SOD1/+), Dync1h1 (Cra1/+) and double (Cra1/SOD1) mutations, at presymptomatic and symptomatic stages (age 70, 140, 365 days) using RT-PCR and Western blotting. The main changes in GST pi expression were observed in mice with the SODG93A mutation. In SOD1/+ and Cra1/SOD1 transgenics, with the exception of cerebellum, the changes in GST pi-mRNA accompanied those in GST pi protein. In brain cortex of both groups the expression was unchanged at the presymptomatic (age 70 days) but was lower at the symptomatic stage (age 140 days) and at both stages in hippocampus and spinal cord of SOD1/+ but not of Cra1/SOD1 mice compared to age-matched wild-type controls. In cerebellum of the presymptomatic and the symptomatic SOD1/+ mice and presymptomatic Cra1/SOD1 mice, the GST pi-mRNA was drastically elevated but the protein level remained unchanged. In Cra1/+ transgenics there were no changes in GST pi expression in any CNS region both on the mRNA and on the protein level. It can be concluded that the SOD1G93A but not the Dync1h1 mutation significantly decreases detoxification efficiency of GST pi in CNS, however the Dync1h1 mutation reduces the effects caused by the SOD1G93A mutation. Despite similarities in neurological symptoms, the differences in GST pi expression between SOD1/+ and Cra1/+ transgenics indicate a distinct pathogenic entity of these two conditions.
16

Maximum daily rainfall analysis at selected meteorological stations in the upper Lusatian Neisse River basin

51%
Wdowikowski M., Kazmierczak B., Ledvinka O.
Meteorology Hydrology and Water Management. Research and Operational Applications
|
2016
|
tom 04
|
nr 1
The scope of this study was to assess the usefulness of top probability distributions to describe maximum rainfall data in the Lusatian Neisse River basin, based on eight IMWM-NRI meteorological stations. The research material was composed of 50-year precipitation series of daily totals from 1961 to 2010. Misssing measurement data were estimated using a weighted average method. Homogeneity for refilled data were investigated by precipitation double aggregation curve. Correlation between the measurement data varied from 96 to 99% and did not indicate a violation of the homogeneity of rainfall data series. Variability of recorded daily precipitation maxima were studied by linear regression and non-parametric Mann-Kendall tests. Long-term period changes at maximum rainfalls for four stations remained statistically insignificant, and for the other four were significant, although the structure of maximums was relatively similar. To describe the measured data, there were used the Fréchet, Gamma, Generalized Exponential Distribution (GED), Gumbel, Log-normal and Weibull distributions. Particular distribution parameters were estimated using the maximum likelihood method. The conformity of the analyzed theoretical distributions with measured data was inspected using the Schwarz Bayesian information criterion (BIC) and also by the relative residual mean square error (RRMSE). Among others, the Gamma, GED, and Weibull distributions fulfilled the compliance criterion for each meteorological station respectively. The BIC criterion indicated GED as the best; however differences were minor between GED on the one hand and the Gamma and Weibull distributions on the other. After conducting the RRMSE analysis it was found that, in comparison to the other distributions, GED best describes the measured maximum rainfall data.
17

Changes in kinesin expression in the CNS of mice with dynein heavy chain 1 mutation

51%
Kuzma-Kozakiewicz M., Kazmierczak B., Usarek E., Baranczyk-Kuzma A.
Acta Biochimica Polonica
|
2013
|
tom 60
|
nr 1
 Dysfunction of fast axonal transport, vital for motor neurons, may lead to neurodegeneration. Anterograde transport is mediated by N-kinesins (KIFs), while retrograde transport by dynein 1 and, to a minor extent, by C-kinesins. In our earlier studies we observed changes in expression of N- and C-kinesins (KIF5A, 5C, C2) in G93ASOD1-linked mouse model of motor neuron degeneration. In the present work we analyze the profile of expression of the same kinesins in mice with a dynein 1 heavy chain mutation (Dync1h1, called Cra1), presenting similar clinical symptoms, and in Cra1/SOD1 mice with milder disease progression than SOD1 transgenics. We found significantly higher levels of mRNA for KIF5A and KIF5C but not the KIFC2 in the frontal cortex of symptomatic Cra1/+ mice (aged 365 days) compared to the wild-type controls. No changes in kinesin expression were found in the spinal cord of any age group and only mild changes in the hippocampus. The expression of kinesins in the cerebellum of the presymptomatic and symptomatic mice (aged 140 and 365 days, respectively) was much lower than in age-matched controls. In Cra1/SOD1 mice the changes in KIFs expression were similar or more severe than in the Cra1/+ groups, and they also appeared in the spinal cord. Thus, in mice with the Dync1h1 mutation, which impairs dynein 1-dependent retrograde transport, expression of kinesin mRNA is affected in various structures of the CNS and the changes are similar or milder than in mice with double Dync1h1/hSOD1G93A mutations.
18

Ekspresja transferazy S-glutationowej pi w osrodkowym ukladzie nerwowym myszy podczas starzenia

45%
Kazmierczak B., Usarek E., Gajewska B., Kuzma M., Baranczyk-Kuzma A.
Medycyna Weterynaryjna
|
2005
|
tom 61
|
nr 05
577-579
19

Glutathione S-transferase pi as a target for tricyclic antidepressants in human brain

45%
Baranczyk-Kuzma A., Kuzma M., Gutowicz M., Kazmierczak B., Sawicki J.
Acta Biochimica Polonica
|
2004
|
tom 51
|
nr 1
GST pi, the main glutathione S-transferase isoform present in the human brain, was isolated from various regions of the brain and the in vitro effect of tricyclic anti­depressants on its activity was studied. The results indicated that amitripyline and doxepin — derivatives of dibenzcycloheptadiene, as well as imipramine and clomipramine — derivatives of dibenzazepine, inhibit the activity of GST pi from frontal and parietal cortex, hippocampus and brain stem. All these tricyclics are non- competitive inhibitors of the enzyme with respect to reduced glutathione and non- competitive (amitripyline, doxepin) or uncompetitive (imipramine, clomipramine) with respect to the electrophilic substrate. Their inhibitory effect is reversible and it depends on the chemical structure of the tricyclic antidepressants rather than on the brain localization of the enzyme. We conclude that the interaction between GST pi and the drugs may reduce their availability in the brain and thus affect their therapeutic activity. On the other hand, tricyclic antidepressants may decrease the efficiency of the enzymatic barrier formed by GST and increase the exposure of brain to toxic electrophiles. Reactive electrophiles not inactivated by GST may contribute in adverse effects caused by these drugs.
20

Zmiany w ekspresji izoform bialka tau w mozgu myszy w zaleznosci od wieku

39%
Usarek E., Kuzma M., Kazmierczak B., Muench C., Ludolph A. C., Baranczyk-Kuzma A.
Medycyna Weterynaryjna
|
2006
|
tom 62
|
nr 02
231-233
au is a microtubule-associated protein important for the assembly and stabilization of microtubules. Six tau isoforms are produced in the central nervous system from one single gene as a result of the alternative splicing of exons 2, 3 (N-terminal part) and exon 10 (C-terminal part). The shortest isoform (2-3-10-, 0N 3R) is characteristic for fetal brains, whereas the remaining (2+3-10-, 1N 3R; 2+3+10-, 2N 3R; 2-3-10+, 0N 4R; 2+3-10+, 1N 4R; 2+3+10+, 2N 4R) for adult brains. The aim of the study was to establish a profile of tau protein variants in the C57BL/6J mouse frontal cortex during the aging process. The total RNA was isolated from tissues, followed by reverse transcription and PCR reaction. It was found that the sequence encoded by exon 10 was absent in the youngest 5-day old newborns (isoform 3R), while it was present in 21, 70 and 140-day old animals (isoform 4R). The most abundant isoform in 5-day old mice was 1N and accounted for 66% of the total tau protein. The percentage of 1N isoforms lowered with age and was 31% in 140-day old animals. The total percentage of 0N isoforms was 11% in 5-day old mice and was approximately threefold lower than in each of the older groups. It may be concluded that alternative splicing of the tau protein undergoes age-dependent regulation in the mouse brain cortex.
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