Wyniki wyszukiwania

Sortuj według:

Ogranicz wyniki do:

Inhibition of the helicase activity of HCV NTPase-helicase by 1-beta-D-ribofuranosyl-1,2,4-triazole-3-carboxamide-5'-triphosphate [ribavirin-TP]

100%

Borowski P., Lang M., Niebuhr A., Haag A., Schmitz H., Schulze zur Wiesch J., Choe J., Siwecka M. A., Kulikowski T.

Acta Biochimica Polonica

2001

tom 48

nr 3

In the presented study the ribavirin-TP — an established inhibitor of the NTPase activity of the superfamily NTPase/helicases II — was investigated as an inhibitor of the unwinding activity of the hepatitis C virus (HCV) NTPase/helicase. The kinetics of the reaction revealed that ribavirin-TP reduces the turnover number of the helicase reaction by a mechanism that does not correspond to that of the inhibition of the NTPase activity. Our results suggest that derivatives of ribavirin-TP with enhanced stability towards hydrolytic attack may be effective inhibitors of the enzyme.

Ograniczanie wyników

1 Acta Biochimica Polonica

1 Borowski P.

1 Choe J.

1 Haag A.

1 Kulikowski T.

1 Lang M.

1 Niebuhr A.

1 Schmitz H.

1 Schulze zur Wiesch J.

1 Siwecka M. A.

1 2001

Wyniki wyszukiwania

Inhibition of the helicase activity of HCV NTPase-helicase by 1-beta-D-ribofuranosyl-1,2,4-triazole-3-carboxamide-5'-triphosphate [ribavirin-TP]