Wyniki wyszukiwania

Sortuj według:

Ogranicz wyniki do:

Blockade of calcium channels and AT1 receptors prevents the hypertensive effect of calcilytic NPS 2143 in rats

100%

Rybczynska A., Jurska-Jasko A., Boblewski K., Lehmann A., Orlewska C.

Journal of Physiology and Pharmacology

2010

tom 61

nr 2

Calcilytics, antagonists of calcium receptor, decrease sensitivity of this receptor to plasma calcium concentration and increase parathyroid hormone (PTH) secretion. Moreover, it was recently indicated that calcilytic NPS 2143 induces hypertension in rats. This study tested whether the increase of mean arterial blood pressure (MAP) induced by NPS 2143 administration is mediated by calcium channel and angiotensin II type1 (AT1) receptor activity. Wistar rats were anaesthesized with Thiopental i.p. and infused i.v. with saline supplemented with the anaesthetic. Blood pressure was monitored continuously in the carotid artery. Effects of NPS 2143 administered i.v. as bolus on MAP in the presence and absence of felodypine and losartan were investigated. Both, felodipine and losartan pretreatment provoked a persistent MAP decrease by 18±3 and 14±3 mmHg, respectively. Infusion of NPS 2143 at 1 mg/kg b.w. confirmed hypertensive activity of calcilytic and increased blood pressure for 21±4 mmHg. In contrast, administration of NPS 2143 in felodipine as well as in losartan pretreated rats did not change MAP as compared to felodipine/control and losartan/control groups, respectively. Our study indicated that both the blockade of calcium channels and the AT1 receptor activity prevented the hypertensive effect of calcilytic NPS 2143. This finding might be particularly important in understanding the mechanisms that mediated blood pressure changes related to the activity of calcium receptor.

Formation of 4-pyridone-3-carboxamide1-β-d-ribonucleoside triphosphate in the erythrocytes, endothelium and cardiomyocytes and its effect on atp concentration

72%

Slominska E.-M., Romaszko P., Lipinski M., Orlewska C., Osman L., Yuen A.-H., Siedlecka U., Foks H., Terracciano C., Smolenski R.-T.

Acta Biochimica Polonica

2007

tom 54

nr Supplement 4

Ograniczanie wyników

1 Acta Biochimica Polonica

1 Journal of Physiology and Pharmacology

2 Orlewska C.

1 Boblewski K.

1 Foks H.

1 Jurska-Jasko A.

1 Lehmann A.

1 Lipinski M.

1 Osman L.

1 Romaszko P.

1 Rybczynska A.

1 Siedlecka U.

1 Slominska E.-M.

1 Smolenski R.-T.

1 Terracciano C.

1 Yuen A.-H.

1 2010

1 2007

Wyniki wyszukiwania

Blockade of calcium channels and AT1 receptors prevents the hypertensive effect of calcilytic NPS 2143 in rats

Formation of 4-pyridone-3-carboxamide1-β-d-ribonucleoside triphosphate in the erythrocytes, endothelium and cardiomyocytes and its effect on atp concentration