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Different gene expression profiles of AD293 and HEK293 cell lines that show contrasting susceptibility to apoptosis induced by overexpression of Bim L

100%

Zhang J., Chen J., Liu L., Ji C., Gu S., Ying K., Mao B.

Acta Biochimica Polonica

2006

tom 53

nr 3

cDNA cloning, gene organization and expression analysis of human peptidylarginine deiminase type VI

68%

Zhang J., Dai J., Zhao E., Lin Y., Zeng L., Chen J., Zheng H., Wang Y., Li X., Ying K., Xie Y., Mao Y.

Acta Biochimica Polonica

2004

tom 51

nr 4

Peptidylarginine deiminase (PAD) catalyzes the post-translational modification of protein through the conversion of arginine to citrulline in the presence of calcium ions. Human, similar to rodents, has four isoforms of PAD (type I, II, III and IV/V), each of which is distinct in substrate specificity and tissue specific expression. In our large-scale sequencing project, we identified a new human PAD cDNA from a human fetal brain cDNA library. The putative protein encoded by this cDNA is designated hPADVI. Expression analysis of hPADVI showed that it is mainly expressed in adult human ovary and peripheral blood leukocytes. We conclude that hPADVI may be orthologous to mouse ePAD, basing on sequence comparison, chromosome localization and exon-intron structure analysis. PAD-mediated deimination of epithelial cell keratin resulting in cytoskeletal remodeling suggests a possible role for hPADVI in cytoskeletal reorganization in the egg and in early embryo development. This study describes a new important member of the human PAD family.

Ograniczanie wyników

2 Acta Biochimica Polonica

2 Chen J.

2 Ying K.

2 Zhang J.

1 Dai J.

1 Gu S.

1 Ji C.

1 Li X.

1 Lin Y.

1 Liu L.

1 Mao B.

1 Mao Y.

1 Wang Y.

1 Xie Y.

1 Zeng L.

1 Zhao E.

1 Zheng H.

1 2006

1 2004

Wyniki wyszukiwania

Different gene expression profiles of AD293 and HEK293 cell lines that show contrasting susceptibility to apoptosis induced by overexpression of Bim L

cDNA cloning, gene organization and expression analysis of human peptidylarginine deiminase type VI