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Pharmacokinetic disposition of pethidine under tolerance

100%

Szczawinska K., Cenajek-Musial D., Nowakowska E., Chodera A.

Acta Physiologica Polonica

1989

tom 40

nr 4

Szczawińska, K., Cenajek-Musiał, D., Nowakowska, E. and Chodera, A.: Pharmacokinetic disposition of pethidine under tolerance. Acta physiol pol., 1989, 40 (4): 374-380. Under tolerance, evoked by multiple doses of pethidine (PD), the serum and brain tissue content of PD was related to diminished analgesic activity. Even though in tolerant rats no enhancement of PD biotransformation in the liver could be recognized (as followed by the measurement of hepatic esterase and N-demethylase activity), the amounts of both PD and nor-PD excreted in urine were increased under tolerance. The authors conclude that the faster disposition of PD may contribute to the development of tolerance.

Polyamines attenuate the catalepsy elicited by haloperidol

100%

Szczawinska K., Cenajek-Musial D., Kwiatkowski P.

Acta Neurobiologiae Experimentalis

1995

tom 55

nr 5

Ograniczanie wyników

1 Acta Neurobiologiae Experimentalis

1 Acta Physiologica Polonica

2 Cenajek-Musial D.

2 Szczawinska K.

1 Chodera A.

1 Kwiatkowski P.

1 Nowakowska E.

1 1995

1 1989

Wyniki wyszukiwania

Pharmacokinetic disposition of pethidine under tolerance

Polyamines attenuate the catalepsy elicited by haloperidol