Ten six-week-old White Large piglets were administered resveratrol (res) in a daily dose of 3 mg /kg0,75 b.w. Another ten piglets were used as controls. Both groups were housed in individual pens, fed ad libitum a complete feed mixture. Blood samples were collected from v. jugularis at the beginning of weeks 1 and 2 of the experiment. The total number and different types of white blood cells (WBC) were determined. The percentage of phagocytising cells (PB values) and the phagocyte activity index (PAI) were determined in neutrophils. The administration of res caused a significant decrease in the number of WBC (P<0.01) at the end of week 1. The decrease was recorded in the number of lymphocytes (P<0.01) and almost to half in neutrophils (P<0.01), particularly in young cell band-forms (P<0.01). After two weeks of res administration no further reduction in leukocyte count was found. In the controls, a significant (P<0.01) decrease in WBC, caused by the reduced number of lymphocytes (P<0.05), was observed only at the end of the experiment and the number of neutrophils remained unchanged. The number of bands at the end of the first week was even significantly higher (P<0.05). Res lowered PB (P<0.05) and the PAI (P<0.01) values at the end of the experiment. It can be concluded that res caused a significant, although only temporary, suppression of leukopoiesis, with a consequent decrease in neutrophil phagocyte activity.
JavaScript jest wyłączony w Twojej przeglądarce internetowej. Włącz go, a następnie odśwież stronę, aby móc w pełni z niej korzystać.