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Ocena przydatności testu adherencji in vitro w badaniach nad przyleganiem drożdżaków do różnych rodzajów nabłonków organizmu wyższego

100%

Macura A. B.

Diagnostyka Laboratoryjna

|

1985

|

tom 21

|

nr 6

2

Występowanie i rola grzybów lipofilnych na skórze

100%

Macura A. B.

Postępy Mikrobiologii

|

1983

|

tom 22

|

nr 3-4

3

Przyleganie grzybów drożdżopodobnych do komórek ssaków

100%

Macura A. B.

Postępy Mikrobiologii

|

1987

|

tom 26

|

nr 4

4

Przyleganie grzybow z rodzaju Candida do komorek ssakow

100%

Macura A. B.

Postępy Mikrobiologii

|

1993

|

tom 32

|

nr 4

321-336

5

Adherence of Candida to mucosaal epithelial cells

75%

Macura A. B.

Acta Microbiologica Polonica

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1985

|

tom 34

|

nr 1

6

Expression changes of estrogen receptors alpha and beta in testis and epididymis of male mice under the influence of diet rich in phytoestrogens

63%

Sliwa L., Macura A. B.

Acta Biologica Cracoviensia. Series Botanica. Supplement

|

2008

|

tom 50

|

nr 1

7

Air-conditioning vs. presence of pathogenic fungi in hospital operating theatre environment

63%

Gniadek A., Macura A. B.

Wiadomości Parazytologiczne

|

2011

|

tom 57

|

nr 2

Infections related to modern surgical procedures present a difficult problem for contemporary medicine. Infections acquired during surgery represent a risk factor related to therapeutical interventions. Eradication of microorganisms from hospital operating theatre environment may contribute to reduction of infections as the laminar flow air-conditioning considerably reduces the number of microorganisms in the hospital environment. The objective of the study was to evaluate the occurrence of fungi in air-conditioned operating theatre rooms. The study was carried out in one of the hospitals in Kraków during December 2009. Indoor air samples and imprints from the walls were collected from five operating theatre rooms. A total of fifty indoor air samples were collected with a MAS-100 device, and twenty five imprints from the walls were collected using a Count Tact method. Fungal growth was observed in 48 air samples; the average numbers of fungi were within the range of 5–100 c.f.u. in one cubic metre of the air. Fungi were detected only in four samples of the wall imprints; the number of fungi was 0.01 c.f.u. per one square centimetre of the surface. The mould genus Aspergillus was most frequently isolated, and the species A. fumigatus and A. versicolor were the dominating ones. To ensure microbiological cleanness of hospital operating theatre, the air-conditioning system should be properly maintained. Domination of the Aspergillus fungi in indoor air as well as increase in the number of moulds in the samples taken in evenings (p<0.05) may suggest that the room decontamination procedures were neglected.

8

Wplyw proteinazy gronkowcowej na przyleganie grzybow Candida albicans do komorek blony sluzowej in vitro

63%

Miedzobrodzki J., Macura A. B.

Medycyna Doświadczalna i Mikrobiologia

|

1993

|

tom 45

|

nr 2

245-247

9

Dental care for cancer patients undergoing radiotherapy of the head and neck region

63%

Pytko-Polonczyk J., Macura A. B.

Journal of Pre-Clinical and Clinical Research

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2012

|

tom 06

|

nr 2

10

Wpływ enzymów na przyleganie grzybów z rodzaju Candida do komórek błony śluzowej policzka in vitro

63%

Macura A. B., Bankowska B.

Medycyna Doświadczalna i Mikrobiologia

|

1989

|

tom 41

|

nr 2

11

Wplyw stopnia uposledzenia odpornosci na wystepowanie i postac grzybicy jamy ustnej u pacjentow zakazonych wirusem HIV

63%

Bort A., Macura A. B.

Medycyna Doświadczalna i Mikrobiologia

|

2003

|

tom 55

|

nr 2

181-187

Oceniono klinicznie i mykologicznie występowanie kandydozy jamy ustnej u chorych, o różnym stopniu upośledzenia odporności, zakażonych wirusem HIV. Częstość występowania grzybicy i jej postać oraz obfitość grzybów w wymazach z jamy ustnej były zależne od stopnia upośledzenia odporności, wyrażonego liczbą limfocytów CD4.

12

Przeciwgrzybiczna aktywnosc flukonazolu in vitro

63%

Pawlik B., Macura A. B.

Medycyna Doświadczalna i Mikrobiologia

|

1995

|

tom 47

|

nr 1-2

101-106

13

In vitro antifungal susceptibility testing of Scopulariopsis brevicaulis strains using agar diffusion method

63%

Skora M., Macura A. B.

Wiadomości Parazytologiczne

|

2011

|

tom 57

|

nr 2

The genus Scopulariopsis is a common soil saprotroph and has been isolated from air, organic waste and also from plant, animal and human tissues. Scopulariopsis has mainly been associated in humans with superficial mycoses, but it has also been described as the cause of subcutaneous and invasive infections. The most common aetiological agent of infections in humans is Scopulariopsis brevicaulis. This species has been reported to be resistant in vitro to broad-spectrum antifungal agents available today. The aim of the study was to establish in vitro antifungal susceptibility of 35 S. brevicaulis strains against amphotericin B (AMB), flucytosine (FC), caspofungin (CAS), terbinafine (TER), ciclopirox (CIC), voriconazole (VOR), clotrimazole (CTR), miconazole (MCZ), econazole (ECO), ketoconazole (KET), itraconazole (ITR), and fluconazole (FLU). Antifungal susceptibility tests were evaluated by an agar diffusion method (Neo-Sensitabs, Rosco, Denmark). AMB, FC, CAS, ITR and FLU showed no antifungal activity against S. brevicaulis. TER, CIC, CTR, KET, VOR, ECO, and MCZ revealed inhibitory activity for S. brevicaulis, but it varied for each of the drugs. The best antifungal effect was observed for TER and CIC. All isolates had large inhibition zones for TER and CIC. CTR was also inhibitory for all tested S. brevicaulis isolates, but the diameters of inhibition zones were smaller than for TER and CIC. Nearly 89% isolates showed inhibition zones for KET and the mean diameter of the inhibition zone was comparable to CTR. The least antifungal activity exhibited VOR, ECO and MCZ. Because of the multiresistance of S. brevicaulis, infections due to this species may not respond to particular antifungal treatment and other therapeutic approaches should be considered e.g., combined therapy and/or surgery.

14

Hydrofobowość i zdolność adherencji szczepów Candida wyizolowanych od ludzi chorych na grzybicę

63%

Macura A. B., Syslo J.

Medycyna Doświadczalna i Mikrobiologia

|

1990

|

tom 42

|

nr 1-2

15

Wpływ syntetycznych leków przeciwgrzybicznych na przyleganie grzybów Candida albicans in vitro do nabłonka jamy ustnej

63%

Macura A. B., Dwernicka B.

Medycyna Doświadczalna i Mikrobiologia

|

1989

|

tom 41

|

nr 1

16

Evaluation of adhesive properties of Candida albicans isolated from the oral cavity in HIV positive patients

63%

Macura A. B., Bort A.

Wiadomości Parazytologiczne

|

2001

|

tom 47

|

nr 4

The aim of the work was to compare adhesive properties of Candida albicans strains isolated from the oral cavity in HIV+ vs. HIV- persons. The materials were Candida albicans strains and buccal epithelial cells isolated from both HIV+ and HIV- persons. We applied the in vitro adherence test, primarily described by Kimura and Pearsall and modified by Macura. The strongest adherence was found between both fungi and epithelial cells isolated from a HIV+ person. The adherence of C. albicans isolated from HIV+ patients was significantly stronger to epithelium collected from HIV+ than HIV- persons.

17

Podatnosc plytek paznokciowych na zakazenia Scopulariopsis brevicaulis

51%

Macura A. B., Pawlik B., Perun M., Krol M.

Wiadomości Parazytologiczne

|

2002

|

tom 48

|

nr 4

333-342

Nail plate susceptibility 10 Scopulariopsis brevicaulis infection. Experimental Scopulariopsis brevicaulis infection of toe and finger nails collected from 79 persons of both sexes and at various age is presented. Crumbled nail fragments were incubated with a S. brevicaulis strain isolated from toenail acauliosis. The culture was inspected and evaluated under light microscope after seven days of incubalion. Hyphe intensively penetrating nail fragments were found in 67.1% of toenails and 38% of fingernails. The infection was most intensive in the nails collected from males and elderly persons.

18

Ocena in vitro grzybow z rodzaju Aspergillus i Penicillium na nowe leki przeciwgrzybicze

51%

Macura A. B., Pawlik B., Szczepko I.

Wiadomości Parazytologiczne

|

2000

|

tom 46

|

nr 1

157-162

Fifty four mould strains (32 Aspergillus and 22 Penicillium) isolated from clinical materials were tested using dilution method. Two test media were used: Yeast Nitrogen Base (YNB) and Czapek Dox (CD). The following drugs were tested: amorolfine, cyclopirox, itraconazole, and terbinafine. In the dilution method, the drugs were tested at four contrentrations: 0.1 mg/l, 1 mg/l, 10 mg/l, and 100 mg/l. No matter which medium and/or drug was used, terbinafine turned out to be most effective. The drug at a conceatration of 1 mg/l inhibited 88.9% of the strains in the CD medium. The MIC values in the YNB medium varied from 0,1 mg/l through 100 mg/1, however, 50% of the strains were inhibited at 1 mg/l or less. Itraconazole revealed a fairly good in vitro antifungal action, particularly in the CD medium: 77.8% of the strains were inhibited at 10 mg/l or less. Aspergillus fumigatus and Aspergillus flavus were most susceptible to itraconazole. The MIC values of cyclopirox amounted to 100 mg/l for all of the strains in the CD medium but not in the YNB where they varied from 1 mg/l to 100 mg/l. Amorolfine was the least effective drug. Most of the strains were inhibited at a concentration of at least 100 mg/l. The findings give evidence that the susceptibility of Aspergillus and Penicillium to the particular drugs is different, and that the results are influenced by the test medium.

19

Histological changes in the mouse testis during LPS-induced inflammation

51%

Macura A. B., Majewska M., Sliwa L., Szczepanik M.

Acta Biologica Cracoviensia. Series Botanica. Supplement

|

2008

|

tom 50

|

nr 1

20

Wystepowanie grzybow w kale u dzieci

51%

Pawlik B., Macura A. B., Bialek-Kaleta J.

Medycyna Doświadczalna i Mikrobiologia

|

2002

|

tom 54

|

nr 3

273-279

W pracy wykonano analizę ilościową i jakościową flory mykologicznej w przewodzie pokarmowym dzieci z nieswoistymi dolegliwościami przewodu pokarmowego oraz u dzieci z zewnątrzpochodną i wewnątrzpochodną astmą oskrzelową. Oceniono również oporność wyizolowanych grzybów na leki przeciwgrzybicze.

Ograniczanie wyników

Ocena przydatności testu adherencji in vitro w badaniach nad przyleganiem drożdżaków do różnych rodzajów nabłonków organizmu wyższego

Występowanie i rola grzybów lipofilnych na skórze

Przyleganie grzybów drożdżopodobnych do komórek ssaków

Przyleganie grzybow z rodzaju Candida do komorek ssakow

Adherence of Candida to mucosaal epithelial cells

Expression changes of estrogen receptors alpha and beta in testis and epididymis of male mice under the influence of diet rich in phytoestrogens

Air-conditioning vs. presence of pathogenic fungi in hospital operating theatre environment

Wplyw proteinazy gronkowcowej na przyleganie grzybow Candida albicans do komorek blony sluzowej in vitro

Dental care for cancer patients undergoing radiotherapy of the head and neck region

Wpływ enzymów na przyleganie grzybów z rodzaju Candida do komórek błony śluzowej policzka in vitro

Wplyw stopnia uposledzenia odpornosci na wystepowanie i postac grzybicy jamy ustnej u pacjentow zakazonych wirusem HIV

Przeciwgrzybiczna aktywnosc flukonazolu in vitro

In vitro antifungal susceptibility testing of Scopulariopsis brevicaulis strains using agar diffusion method

Hydrofobowość i zdolność adherencji szczepów Candida wyizolowanych od ludzi chorych na grzybicę

Wpływ syntetycznych leków przeciwgrzybicznych na przyleganie grzybów Candida albicans in vitro do nabłonka jamy ustnej

Evaluation of adhesive properties of Candida albicans isolated from the oral cavity in HIV positive patients

Podatnosc plytek paznokciowych na zakazenia Scopulariopsis brevicaulis

Ocena in vitro grzybow z rodzaju Aspergillus i Penicillium na nowe leki przeciwgrzybicze

Histological changes in the mouse testis during LPS-induced inflammation

Wystepowanie grzybow w kale u dzieci