Wyniki wyszukiwania

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Nerve growth factor injected into the gastric ulcer base incorporates into endothelial, neuronal, glial and epithelial cells: implications for angiogenesis, mucosal regeneration and ulcer healing

100%

Tanigawa T., Ahluwalia A., Watanabe T., Arakawa T., Tarnawski A. S.

Journal of Physiology and Pharmacology

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2015

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tom 66

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nr 4

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TGF-beta signalling pathway: its role in gastrointestinal pathophysiology and modulation of ulcer healing

100%

Tanigawa T., Pai R., Arakawa T., Higuchi K., Tarnawski A. S.

Journal of Physiology and Pharmacology

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2005

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tom 56

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nr 1

Gastrointestinal ulcer healing is a complex process, involving cell migration, proliferation, angiogenesis and extracellular matrix deposition, all ultimately leading to reconstruction of tissue architecture within the ulcer scar. These processes are controlled by growth factors, cytokines and hormones. Transforming growth factor-ß (TGF-ß ), one of the multifunctional peptide growth factors, has been reported to positively regulate gastrointestinal ulcer healing. Although TGF-ß inhibits cell proliferation in a variety of cells, it induces cell migration, angiogenesis, and enhances extracellular matrix production necessary for gastrointestinal ulcer healing. TGF-ß exerts its action by binding to its transmembrane serine/threonine kinase receptors, which in turn triggers activation of various intracellular signaling pathways. Smads are intermediate effector proteins that play key roles in biological activities of TGF-ß by transmitting the signals from the cell surface directly into the nucleus and initiating transcription. New insight into the mechanisms underlying TGF-ß-Smad modulation of gastrointestinal ulcer healing will likely enhance our understanding of the mechanisms controlling the healing processes of gastrointestinal ulcers.

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Inhibitory effects of indomethacin on growth and proliferation of gastric carcinoma cells Kato III

100%

Fujiwara Y., Tarnawski A., Fujiwara K., Arakawa T., Kobayashi K.

Journal of Physiology and Pharmacology

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1993

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tom 44

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nr 2

4

Isolation of morphologically and functionally intact gastric mucosal microvessels rapid communication

86%

Tarnawski A., Arakawa T., Sekhon S., Ichikawa Y., Szabo I., Sarfeh I. J.

Journal of Physiology and Pharmacology

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2000

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tom 51

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nr 1

Ograniczanie wyników

4 Journal of Physiology and Pharmacology

4 Arakawa T.

2 Tanigawa T.

2 Tarnawski A.

2 Tarnawski A. S.

1 Ahluwalia A.

1 Fujiwara K.

1 Fujiwara Y.

1 Higuchi K.

1 Ichikawa Y.

1 Kobayashi K.

1 Pai R.

1 Sarfeh I. J.

1 Sekhon S.

1 Szabo I.

1 Watanabe T.

1 2015

1 2005

1 2000

1 1993

Nerve growth factor injected into the gastric ulcer base incorporates into endothelial, neuronal, glial and epithelial cells: implications for angiogenesis, mucosal regeneration and ulcer healing

TGF-beta signalling pathway: its role in gastrointestinal pathophysiology and modulation of ulcer healing

Inhibitory effects of indomethacin on growth and proliferation of gastric carcinoma cells Kato III

Isolation of morphologically and functionally intact gastric mucosal microvessels rapid communication