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The present study was designed to evaluate the genotoxicity of albendazole (ABZ) in mice using the micronucleus test. Mice were treated by gavage with 500, 1,000, and 1,500 mg of ABZ kg⁻¹ b.w., which corresponds to 1/6, 1/3, and 1/2 of the oral LD₅₀ of ABZ. In the second part of the study, the possible protective role of vitamin C (vit. C) was investigated against the genotoxic effect of ABZ. The mice received 200 mg of vit C kg⁻¹ b.w. simutaneously with ABZ. Bone marrow samples were taken 48 h after the treatment. ABZ induced a statistically significant increase (P<0.001) in the percentage of micronucleaoted polychromatic erythrocytes (MNPCE) in the 1,000 and 1,500 mg of ABZ kg⁻¹ b.w. treatment groups when compared with the negative control. On the other hand, the percentage of induced MNPCE was reduced at various levels in all ABZ treated groups simultaneously treated with an oral administration of vit. C. There were no statistically significant differences in the MNPCE frequency of these groups. The results of the study indicated that ABZ is a potential genotoxic agent, and that no protective effects of vit. C were observed against the genotoxicity of ABZ.
Background: Mandibular second molars frequently show variation in root canal configurations. The patients with C-shaped canals are quite challenging in dental practice. C-shaped canals have a poor prognosis in terms of debridement, obturation, and restoration. The aim of this study was to investigate the root canal configuration of mandibular second molar teeth and to determine the frequency of C-shaped canals in mandibular second molars. Materials and methods: We designed a retrospective study using cone beam computed tomography (CBCT) images and 256 CBCT images were retrieved from the archived records of Necmettin Erbakan University Faculty of Dentistry, Konya, Turkey. The root canal configurations were evaluated according to Vertucci’s classification and C-shaped canal configurations were identified using the method of Fan et al. The frequency in percentages was calculated for C-shaped canals in CBCT scans. Results: Of the 444 mandibular second molars, the most frequent canal morphology in the mesial roots was Vertucci type IV (40.3%), followed by type II (27.5%). The distal roots were predominantly type I (92.9%), followed by types III (3.5%) and II (2.5%). Forty-seven (10.6%) teeth had C-shaped canals. Conclusions: Clinicians should be concerned about the different types of canal configurations. Knowledge of these anatomical variations will facilitate the endodontic practice. (Folia Morphol 2018; 77, 4: 752–757)
This research was conducted to investigate the effects of phytostimulators application (Messenger, Crop-Set, ISR-2000) on yield and morphological parameters of common bean cultivars grown under four irrigation regimes [25% (I₂₅), 50% (I₅₀), 75% (I₇₅) and 100% (I₁₀₀)]. Phytostimulators reversed the negative effect of drought on plant growth. Significant interaction was determined for all parameters except stem diameter and stomatal conductivity between phytostimulator and drought applications. The best effect on stomatal conductivity was provided from ISR-2000 (23.5% reduction) application. The highest yield was obtained from the 25% water deficiency applied with 1.91 ton per hectare. It was determined that the best results were obtained from Messenger in Efsane and Asya cultivars and ISR-2000 in the Öz Ayşe cultivar on yield. Therefore, it was concluded that the use of phytostimulators under drought stress is important for the effective use of water.
Background: The aim of this study was to compare the morphological differences in the mandible between patients with six age groups and to detect the correlation between these parameters on panoramic radiography (PR) and cone-beam computed tomography (CBCT). Materials and methods: A total of 121 subjects (50 males and 71 females) were included in the study and were divided into six age groups (10–19, 20–29, 30–39, 40–49, 50–59, and 60–69) on the basis of the chronological age. CBCT and PR methods were used to record the mandibular measurements for the same 121 patients. Differences between male and female mandibular morphometric measurements, between right and left side measurements, and differences in age subgroups compared by using independent samples t-test, paired samples t-test, and one-way ANOVA test, respectively. P < 0.05 value was considered statistically significant for all analysis. Results: Males mostly have higher mandibular measurement values. There were statistically significant differences between CBCT and PR measurements (p < 0.05). PR mostly showed higher values than CBCT measurements. Conclusions: Based on the fact that PRs showing significant differences from CBCT in the morphometric measurements made on mandible, it is recommended that forensic doctors and anthropologists consider this information in their age and gender prediction studies. (Folia Morphol 2019; 78, 4: 862–870)
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