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MiR - 34a regulates apoptosis in liver cells by targeting the KLF4 gene

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Chen Q., Li L., Tu Y., Zheng L. L., Liu W., Zuo Y., He Y. M., Zhang S. Y., Zhu W., Cao J. P., Cui F. M., Hou J.

Cellular and Molecular Biology Letters

2014

tom 19

nr 1

MicroRNAs (miRNAs) regulate gene expression by inhibiting translation or targeting messenger RNA (mRNA) for degradation in a posttranscriptional fashion. In this study, we show that ectopic expression of miR-34a-5p reduces the mRNA and protein levels of Krüppel-like factor 4 (KLF4). We also demonstrate that miR-34a targets the 3′-untranslated mRNA region of KLF4 and show that overexpression of miR-34a induces a significant level of apoptosis in BNL CL.2 cells exposed to doxorubicin or 10 Gy X-ray. Our data suggest that the effects of miR-34a on apoptosis occur due to the downregulation of KLF4.

Ograniczanie wyników

1 Cellular and Molecular Biology Letters

1 Cao J. P.

1 Chen Q.

1 Cui F. M.

1 He Y. M.

1 Hou J.

1 Li L.

1 Liu W.

1 Tu Y.

1 Zhang S. Y.

1 Zheng L. L.

1 Zhu W.

1 Zuo Y.

1 2014

Wyniki wyszukiwania

MiR - 34a regulates apoptosis in liver cells by targeting the KLF4 gene