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1

Innovation immunomodulatory treatment - case study of men diagnosed with relapsing-remitting multiple sclerosis (MS)

100%
Siudak M., Cylke D., Tober-Marczewska A.
World Scientific News
|
2017
|
tom 78
2

Coping behavior during the driving license course preparing to the state exam does not correlate with the saliva cortisol and blood pressure during the course

100%
Siudak M., Tober-Marczewska A., Swiergiel A. H., Glac W.
Acta Neurobiologiae Experimentalis
|
2013
|
tom 73
|
nr Suppl.1
We assesed the effectiveness of coping with stress during a 30 hours driving course by people with different levels of stress. Volunteers aged 18–30 took participated: 8 women and 7 men in the control group, and 9 women and 9 men preparing for the exam. Before the start of the course all participants took the Coping Inventory for Stressful Situations (CISS). Saliva samples to measure cortisol were collected from each of the participants: before the start of the course, before the 1st, 13th and 28th driving hour. Blood pressure was measured: before the course, during the 15th hour and the 30th hour of the course. Participants in the control group had one saliva sample taken and their blood pressure was measured once. The results suggest that the hour of the course is related to the level of the cortisol – the highest level is achieved before the first hour of the course and then it decreases in time (ANOVA: F3,64=14.9, P<0.001). Systolic pressure is related to the hour of the course (F2,48=11.3, P<0.001) and it reaches its peak before the state exam. There is a similar relation in case of diastolic pressure (F2,51=6.4, P=0.003). CISS test has shown that there are differences in copying with stress (between sexes as well as age-related).
3

Blood and cerebrospinal fluid biomarkers in Alzheimer's and Parkinson;s diseases

88%
Siudak M., Zietek M., Tober-Marczewska A., Borman A., Swiergiel A. H.
Acta Neurobiologiae Experimentalis
|
2015
|
tom 75
|
nr Supl.
BACKGROUND AND AIMS: Biomarkers are biological indicators that permit qualitative study and quantitative evaluation of various conditions, phenomena or biological features. In modern medicine biomarkers are used for precise and relatively easy diagnosis of chronic diseases, and the assessment of likelihood of their occurrence. Nowadays, it is intensively explored research area for new therapies and biochemical, physiological, histological, morphological, or behavioral types of biomarkers are distinguished. The aim was to explain previously poorly explored correlation between biological markers of stress and neurodegenerative diseases such as Alzheimer’s and Parkinson’s disease and systematization of knowledge. METHODS: PubMed search was used to find the available literature data, key words: biomarkers, Parkinson’s disease, Alzheimer’s disease, blood, cerebrospinal fluid. RESULTS: Parkinson’s disease (PD) is a degenerative disorder of the central nervous system that involves degeneration of dopaminergic neurons in the substantia nigra pars compacta resulting in impairing the motor skills, cognitive process and other function. However, it has been shown that noradrenergic (NAergic) cells from the locus coeruleus also degenerate in this disease. On the other hand, Alzheimer’s disease (AD) is manifested by neocortical and hippocampal atrophy, the deposition of Aβ peptides and the formation of neurofibrillar tangles. AD is a progressive degeneration of cholinergic nuclei in the basal forebrain and of NAergic nuclei in the brainstem. It is considered that neuronal loss is greater in NAergic neurons than cholinergic neurons. CONCLUSIONS: Presented is a succinct review of the role and designation of biological markers in neurodegenerative diseases.
4

Biomarkers in firefighters for behavioral and psychophisical

76%
Siudak M., Tober-Marczewska A., Zietek M., Borman A., Wieczorek M., Swiergiel H.
Acta Neurobiologiae Experimentalis
|
2015
|
tom 75
|
nr Supl.
BACKGROUND AND AIMS: This interdisciplinary project, linking neurophysiology, neuroendocrinology and psychology, aims to explore biomarkers of stress among rescue personnel under emergency situations (catastrophe) and correlating the results of psychophysical features. We expect that an catastrophe produces significant changes in the concentration of biological indicators of stress that may be related to differences in the style of coping with stress. Our hypothesis is that the differences in the concentrations of biomarkers of stress depend on the temperament and ability to learn, assessed by appropriately selected psychological tests. Furthermore, the released hormones affect behavior and, therefore, performance.  The expected results will explain and systematize knowledge about so far poorly explored correlation between the biological markers of stress and psychological parameters in selected professional group. METHODS: The harmful effect of the stressor interpreted as a threat to the individual can affect a variety of intellectual functions. According to Janis (1982) stress is the cause of disturbances in the evaluation and decision-making because it replaces creative ways of responding with rigid and stereotyped thinking (Zimbardo 1999). Activity of the endocrine system will be measured using high performance liquid chromatography (HPLC), while ability to learn, style of coping with stress and temperament would be measured using carefully selected questionnaires and psychological tests under psychologist supervision. RESULTS: In our preliminary research we found that stress associated with start of the practical driving course caused a rise in salivary cortisol that depended only on the time of sampling. CONCLUSIONS: The results may be important by contributing to the development of biological tests to assist in determining the effectiveness of performance under stress conditions. The approach is discussed in the context of current research in the world.
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