Wyniki wyszukiwania

1

Nagroda Nobla 1997: za i przeciw kontrowersyjnej hipotezie

100%

Liberski P. P.

Postępy Mikrobiologii

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1998

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tom 37

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nr 1

9-32

2

The tubulovesicular structures - the ultrastructural hallmark for all prion diseases

100%

Liberski P. P.

Acta Neurobiologiae Experimentalis

|

2008

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tom 68

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nr 1

Tubulovesicular structures (particles – TVS) are the only ultrastructural marker for all prion diseases as seen by thin-section electron microscopy as opposed to "negative-staining" techniques. TVS are spheres or short rods of approximately 27 nm in diameter. That size of TVS is also the size of filter cut-off of infectivity as judged from the ultrafiltration studies and the size of the smallest infectious unit as recently estimated. TVS have been found in all naturally occurring and experimentally induced prion diseases, including variant Creutzfeldt-Jakob disease and human familial TSEs – fatal familial insomnia and Gerstmann-Sträussler-Scheinker disease. In longitudinal studies, the number of neuronal processes containing TVS correlates roughly with the incubation period and with infectivity. Hence, they are readily found in hamsters infected with the 263K strain of scrapie but it is very difficult to find them in human TSEs where titer is lower. The composition of TVS is unknown but they are not composed of PrP. Their consistent presence in all TSEs suggests the unexplained role at least of TSE pathogenesis.

3

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"Ekologia człowieka współczesnego" - Łódź, 10 V 1976 (sesja naukowa)

100%

Liberski P. P.

Wiadomości Parazytologiczne

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1978

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tom 24

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nr 2-3

4

Tubulovesicular structures are present in brains of hamsters infected with the Echigo-1 strain of Creutzfeldt-Jakob disease agent

100%

Liberski P. P.

Acta Neurobiologiae Experimentalis

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2008

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tom 68

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nr 1

Tubulovesicular structures (particles; TVS) are virion-like particles 25–30 nm in diameter found by thin-section electron microscopy in brains of all prion diseases including scrapie, Creutzfeldt-Jakob disease (CJD), fatal familial insomnia (FFI) and Gerstmann-Sträussler-Scheineker disease (GSS), as well as in cell cultures infected with TSE agents. TVS are regarded as a disease-specific ultrastructural marker for TSEs and, by those not completely satisfied with the prion hypothesis, they are even considered to be a possible candidate for the infectious TSE agent itself. A caveat regarding that interpretation stemmed from previous failures to find TVS by electron microscopic studies of tissues from animals infected with the Echigo-1 strain of CJD agent. We now report detecting TVS in brains of hamsters infected with that strain of CJD agent, albeit with a very low frequency.

5

Tubulofilamentous particles are not scrapie-specific and are unrelated to tubulovesicular structures

100%

Liberski P. P.

Acta Neurobiologiae Experimentalis

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1995

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tom 55

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nr 3

6

Tubulovesicular structures [TVS]: virus-like particles specific for all subacute spongiform virus encephalopathies - what are they really?

100%

Liberski P. P.

Archivum Immunologiae et Therapiae Experimentalis

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1994

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tom 42

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nr 2

7

The transmissible brain amyloidoses: a comparison with the non transmissible brain amyloidoses of Alzheimer type

100%

Liberski P. P.

Acta Neurobiologiae Experimentalis

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1993

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tom 53

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nr 1

8

Struktrura czynnika infekcyjnego scrapie

88%

Liberski P. P.

Postępy Biochemii

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1986

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tom 32

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nr 1-2

9

Ultrastructural neuropathology of transgenic mice with human foamy virus is reminiscent of subacute spongiform encephalopathies or AIDA-vacuolating myelopathy

63%

Liberski P. P., Aguzzi A.

Acta Neurobiologiae Experimentalis

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1995

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tom 55

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nr 5

10

Prion diseases: a dual view of the prion hypothesis as seen from a distance

63%

Liberski P. P., Jaskolski M.

Acta Neurobiologiae Experimentalis

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2002

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tom 62

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nr 3

11

Is the prion structure solved?

63%

Liberski P. P., Bratosiewicz-Zapart J.

Archivum Immunologiae et Therapiae Experimentalis

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1997

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tom 45

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nr 2-3

12

Kurt Wuthrich - co-winner of the Nobel Prize in Chemistry, 2002

63%

Jaskolski M., Liberski P. P.

Acta Neurobiologiae Experimentalis

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2002

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tom 62

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nr 4

13

Proliferation of mesaxons in the optic nerve of hamsters infected with the Echigo-1 strain of Creutzfeldt-Jakob disease

63%

Walis A., Liberski P. P.

Acta Neurobiologiae Experimentalis

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1999

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tom 59

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nr 3

14

Ultrastructural studies of scrapie-associated fibrils and prion protein from hamster brains infection with scarpie

51%

Liberski P. P., Plucienniczak A., Hrabec E., Bogucki A.

Folia Histochemica et Cytobiologica

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1989

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tom 27

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nr 1

15

Unusual interaction of astrocytes and oligodendroglia in human and experimental Creutzfeld-Jakob disease and scrapie

51%

Liberski P. P., Yanagihara R., Gajdusek D. C.

Acta Neurobiologiae Experimentalis

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1995

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tom 55

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nr 5

16

Plasma Ab levels as predictors of response to rivastigmine treatment in Alzheimer's disease

51%

Sobow T., Flirski M., Liberski P. P., Kloszewska I.

Acta Neurobiologiae Experimentalis

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2007

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tom 67

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nr 2

Cholinesterase inhibitors are currently the mainstream of symptomatic treatment of patients with Alzheimer's disease. The response to treatment with cholinesterase inhibitors is clinically difficult to predict. Several demographic, clinical and biological variables have been proposed as pretreatment predictors of long-term therapy efficacy. In this paper, consistently with previous reports, we confirm that higher initial disease severity and faster progression of cognitive impairment increase the chance of a clinically meaningful response to cholinesterase inhibitor therapy in a carefully selected population of patients with Alzheimer's disease. Moreover, for the first time we demonstrate the association between the increase in the concentration of plasma Ab1-42 peptide after 2 weeks of treatment with an initial dose of rivastigmine and the likelihood of a positive response to treatment after 6 months. A change in plasma Ab1-42 level might constitute a novel biochemical predictor of rivastigmine treatment efficacy in Alzheimer's diseases.

17

The majority of dystrophic neuritesin Alzheimer disease (AD) and all neurites in Gerstmenn-Straussler-Scheinker disease (GSS) do not contain paired helical filaments and do not express MAP tau (tau)

51%

Liberski P. P., Kloszewska I., Papierz W., Budka H.

Acta Neurobiologiae Experimentalis

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1995

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tom 55

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nr 5

18

Parvovirus particles in a fetal-heart with myocarditis: ultrastructural and immunohistochemical study

51%

Respondek M., Bratosiewicz J., Pertynski T., Liberski P. P.

Archivum Immunologiae et Therapiae Experimentalis

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1997

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tom 45

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nr 5-6

19

How do neurons degenerate in prion diseases or transmissible spongiform encephalopathies [TSEs]: neuronal autophagy revisited

51%

Liberski P. P., Gajdusek D. C., Brown P.

Acta Neurobiologiae Experimentalis

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2002

|

tom 62

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nr 3

20

Distribution of apolipoprotein E4 isoform in Alzheimer's disease in Poland

51%

Bratosiewicz-Zapart J., Kloszewska I., Sobow T., Liberski P. P.

Archivum Immunologiae et Therapiae Experimentalis

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1997

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tom 45

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nr 2-3

Ograniczanie wyników

Nagroda Nobla 1997: za i przeciw kontrowersyjnej hipotezie

The tubulovesicular structures - the ultrastructural hallmark for all prion diseases

"Ekologia człowieka współczesnego" - Łódź, 10 V 1976 (sesja naukowa)

Tubulovesicular structures are present in brains of hamsters infected with the Echigo-1 strain of Creutzfeldt-Jakob disease agent

Tubulofilamentous particles are not scrapie-specific and are unrelated to tubulovesicular structures

Tubulovesicular structures [TVS]: virus-like particles specific for all subacute spongiform virus encephalopathies - what are they really?

The transmissible brain amyloidoses: a comparison with the non transmissible brain amyloidoses of Alzheimer type

Struktrura czynnika infekcyjnego scrapie

Ultrastructural neuropathology of transgenic mice with human foamy virus is reminiscent of subacute spongiform encephalopathies or AIDA-vacuolating myelopathy

Prion diseases: a dual view of the prion hypothesis as seen from a distance

Is the prion structure solved?

Kurt Wuthrich - co-winner of the Nobel Prize in Chemistry, 2002

Proliferation of mesaxons in the optic nerve of hamsters infected with the Echigo-1 strain of Creutzfeldt-Jakob disease

Ultrastructural studies of scrapie-associated fibrils and prion protein from hamster brains infection with scarpie

Unusual interaction of astrocytes and oligodendroglia in human and experimental Creutzfeld-Jakob disease and scrapie

Plasma Ab levels as predictors of response to rivastigmine treatment in Alzheimer's disease

The majority of dystrophic neuritesin Alzheimer disease (AD) and all neurites in Gerstmenn-Straussler-Scheinker disease (GSS) do not contain paired helical filaments and do not express MAP tau (tau)

Parvovirus particles in a fetal-heart with myocarditis: ultrastructural and immunohistochemical study

How do neurons degenerate in prion diseases or transmissible spongiform encephalopathies [TSEs]: neuronal autophagy revisited

Distribution of apolipoprotein E4 isoform in Alzheimer's disease in Poland