The aim of the study was to assess the effectiveness of Mucokehl R in the treatment of leg ulcers. Hie investigation was carried out on 30 patients with lower limbs ulceration randomly divided into 2 groups, where Mucokehl R was administered topically (group II) as well as topically and generally (group I). Hie study revealed the efficacy of MucokehlR in the treatment of leg ulcers, especially when administered in combination (group I) as well as a safety of such a therapeutic approach.