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Kynurenic acid content in anti-rheumatic herbs

100%

Zgrajka W., Turska M., Rajtar G., Majdan M., Parada-Turska J.

Annals of Agricultural and Environmental Medicine

2013

tom 20

nr 4

Plasma kynurenic acid concentration in patients undergoing cardiac surgery: effect of anaesthesia

86%

Kotlinska-Hasiec E., Nowicka-Stazka P., Parada-Turska J., Stazka K., Stazka J., Zadora P., Dabrowski W.

Archivum Immunologiae et Therapiae Experimentalis

2015

tom 63

nr 2

Anti-epileptic drugs inhibit viability of synoviocytes in vitro

86%

Parada-Turska J., Nowicka-Stazka P., Majdan M., Jablonski M., Turski W. A., Rzeski W.

Annals of Agricultural and Environmental Medicine

2013

tom 20

nr 3

Introduction and objective: The hyperplasia of synovial fibroblasts is considered to be essential for the evolution of joint destruction in rheumatoid arthritis (RA). Previously, we reported that anti-rheumatic drugs, both COX inhibitors and disease-modifying anti-rheumatic drugs inhibit proliferation of synoviocytes in vitro. The presented study investigates the effect of anti-epileptic drugs on the viability and proliferation of synovial fibroblasts in vitro. Methods: Experiments were conducted on human synoviocytes derived from an RA patient and rabbit synoviocytes cell line HIG-82. Cell proliferation and viability were assessed by means of BrdU assay and MTT assay, respectively. The IC50 value (the concentration of drug necessary to induce 50% inhibition) together with confidence limits was calculated. Results: Carbamazepine inhibited proliferation of human fibroblasts and viability of HIG-82 with IC50 values of 86 μM and 82 μM, respectively. Diphenylhydantoin, valproate and phenobarbital inhibited viability of HIG-82 cells with the IC50 values of 110, 500 and 1031 μM, respectively. Conclusion: Based on these findings, it can be suggested that anti-epileptic drugs may have a disease-modifying effect on rheumatoid synovial proliferation.

Ograniczanie wyników

2 Annals of Agricultural and Environmental Medicine

1 Archivum Immunologiae et Therapiae Experimentalis

3 Parada-Turska J.

2 Majdan M.

2 Nowicka-Stazka P.

1 Dabrowski W.

1 Jablonski M.

1 Kotlinska-Hasiec E.

1 Rajtar G.

1 Rzeski W.

1 Stazka J.

1 Stazka K.

1 Turska M.

1 Turski W. A.

1 Zadora P.

1 Zgrajka W.

1 2015

2 2013

Wyniki wyszukiwania

Kynurenic acid content in anti-rheumatic herbs

Plasma kynurenic acid concentration in patients undergoing cardiac surgery: effect of anaesthesia

Anti-epileptic drugs inhibit viability of synoviocytes in vitro