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Toxic effects of the crude methanolic extract of Austroplenckia populnea leaves and fractions on the growth of Spodoptera frugiperda

100%

Pires W., Arini L. E. S., Menezes A. C. S., Jesus F. G., Rocha E. C., Araujo M. S.

Acta Agrobotanica

2023

tom 76

Intracerebroventricular physostigmine enhances blood pressure and heat loss in running rats

84%

Pires W., Wanner S. P., La Guardia R. B., Rodrigues L. O. C., Silveira S. A., Coimbra C. C., Marubayashi U., Lima N. R. V.

Journal of Physiology and Pharmacology

2007

tom 58

nr 1

The aim of this study was to evaluate the effects of the stimulation of central cholinergic synapses in the regulation of heat loss in untrained rats during exercise. The animals were separated into two groups (exercise or rest) and tail skin temperature (Ttail), core temperature and blood pressure were measured after injection of 2 µL of 5 x 10-3 M physostigmine (Phy; n = 8) or 0.15 M NaCl solution (Sal; n = 8) into the lateral cerebral ventricle. Blood pressure was recorded by a catheter implanted into the abdominal aorta, Ttail was measured using a thermistor taped to the tail and intraperitoneal temperature (Tb) was recorded by telemetry. During exercise, Phy-treated rats had a higher increase in mean blood pressure (147 ± 4 mmHg Phy vs. 121 ± 3 mmHg Sal; P < 0.001) and higher Ttail (26.4 ± 1.0° C Phy vs. 23.8 ± 0.5° C Sal; P < 0.05) that was closely related to the increase in systolic arterial pressure (r = 0.83; P < 0.001). In addition, Phy injection attenuated the exercise-induced increase in Tb compared with controls without affecting running time. We conclude that the activation of central cholinergic synapses during exercise increases heat dissipation due to the higher increase in blood pressure.

Ograniczanie wyników

1 Acta Agrobotanica

1 Journal of Physiology and Pharmacology

2 Pires W.

1 Araujo M. S.

1 Arini L. E. S.

1 Coimbra C. C.

1 Jesus F. G.

1 La Guardia R. B.

1 Lima N. R. V.

1 Marubayashi U.

1 Menezes A. C. S.

1 Rocha E. C.

1 Rodrigues L. O. C.

1 Silveira S. A.

1 Wanner S. P.

1 2023

1 2007

Wyniki wyszukiwania

Toxic effects of the crude methanolic extract of Austroplenckia populnea leaves and fractions on the growth of Spodoptera frugiperda

Intracerebroventricular physostigmine enhances blood pressure and heat loss in running rats