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Aromatic indolinic aminoxyls as antioxidants in cardiac sarcoplasmic reticulum lipid and protein oxidation

100%

Kulawiak-Galaska D., Wozniak M., Greci L.

Acta Biochimica Polonica

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2002

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tom 49

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nr 1

The results presented demonstrate the influence of aromatic indolinic aminoxyls: 1,2-dihydro-2-ethyl-2-phenyl-3.H-indole-3-phenylimino-1-oxyl (IA-C2) and 1,2-dihydro- 2-octadecyl-2-phenyl-3.H-indole-3-phenylimino-1-oxyl (IA-C18) on oxidation of lipids and proteins of cardiac sarcoplasmic reticulum membranes. We have used doxorubicin and t-butyl hydroperoxide as agents inducing oxidative stress in isolated rat cardiac sarcoplasmic reticulum membrane system. Carbonyl groups were measured as the end product of membrane protein oxidation, and thiobarbituric acid reactive substances were assessed as a marker of lipid pero- xidation. Inhibition of peroxidation of certain membrane components depends on the length of acyl chain. Aminoxyl IA-C2 inhibits the lipid peroxidation process while IA-C18 is an efficient protector against protein oxidation.

2

Catechol estrogen displays protective effect on albumin- important extracellular antioxidant being exposed to peroxyl radical generating system

76%

Figarski A., Walczak P., Szymendera J., Powierza T., Greci L., Wozniak M.

Acta Biochimica Polonica

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2003

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tom 50

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nr Supplement 1

3

Development of novel aromatic aminoxyl tools to detected reactive oxygen species in metmyglobin dependent oxdizing system

76%

Mickiewicz W., Zajworoniuk H., Sarnowski T., Nowak J., Greci L., Wozniak M.

Acta Biochimica Polonica

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2003

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tom 50

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nr Supplement 1

4

Quinolinic aminoxyl as a molecular sensor of peroxidative activity of cytochrome P-450 2B1

76%

Szelagowska A., Meyer-Szary J., Mickiewicz W., Zajworoniuk H., Greci L., Wozniak M.

Acta Biochimica Polonica

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2003

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tom 50

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nr Supplement 1

Ograniczanie wyników

4 Acta Biochimica Polonica

4 Greci L.

4 Wozniak M.

2 Mickiewicz W.

2 Zajworoniuk H.

1 Figarski A.

1 Kulawiak-Galaska D.

1 Meyer-Szary J.

1 Nowak J.

1 Powierza T.

1 Sarnowski T.

1 Szelagowska A.

1 Szymendera J.

1 Walczak P.

3 2003

1 2002

Aromatic indolinic aminoxyls as antioxidants in cardiac sarcoplasmic reticulum lipid and protein oxidation

Catechol estrogen displays protective effect on albumin- important extracellular antioxidant being exposed to peroxyl radical generating system

Development of novel aromatic aminoxyl tools to detected reactive oxygen species in metmyglobin dependent oxdizing system

Quinolinic aminoxyl as a molecular sensor of peroxidative activity of cytochrome P-450 2B1