The aim of the study executed with the perpendicular strip method with three replications, conducted at the Experimental Department of Variety Evaluation in Krościna Mała in the years 2010–2012, was to determine how varieties of oat seeds would respond to the recommended and half of the recommended dose of herbicides for weed reduction, the size of grain yields, its structure and grain quality. Two varieties of oat were tested: Arden and Haker, which were sprayed during tillering with following herbicides: Starane 250 EC at doses of 0.4 and 0.8 l/ha and Chwastox Turbo 340 SL at doses of 1.0 and 2.0 l/ha. The listed herbicides, regardless of the dose, had a positive effect on the reduction of weed infestation, resulting in the increase of grain yield in relation to the controlled objects where no herbicides were used. The analysis of the structure of crops has shown that grain yields on combinations protected by herbicides resulted from increased stocking panicles per unit area, while the 1,000 grain weight and the number of grains per panicle followed a similar pattern as in the control plots. Herbicides used in the cultivation of oat increased the total protein content in grain and the share of grain yield with a diameter above 2.5 mm.