Padma 28 is a combination of Tibetan herbs that is very often used in the western medicine. The present standard of modern phytotherapy requires controlled clinical studies to determine the therapeutic value of herbal preparation. In our review we present controlled clinical studies of Padma 28 in patients with intermittent claudication, juvenile chronic arthritis, multiple sclerosis and angina pectoris. In all the studies safety and tolerability levels were very high. We try also to discuss possible mechanisms of activity of this herbal product.