Wyniki wyszukiwania

1

Rola szlaku sygnalowego Wnt i bialka APC w etiologii raka okreznicy

100%

Cebrat M., Strzadala L.

Postępy Higieny i Medycyny Doświadczalnej

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2001

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tom 55

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nr 4

513-524

2

18th Polish Peptide Symposium

100%

Szewczuk Z., Cebrat M.

Acta Biochimica Polonica

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2006

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tom 53

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nr 1

3

Identification of a novel protein encoded by third conserved gene within RAG locus

81%

Kasztura M., Miazek A., Cebrat M., Kisielow P.

Acta Biochimica Polonica

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2009

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tom 56

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nr 1

177-181

Recently, a third evolutionarily conserved gene, NWC, was discovered within the recombination activating gene (RAG) locus, known to contain the RAG1 and RAG2 genes. Here, we identify and characterize the murine endogenous NWC protein which has no homology to any known protein and is ubiquitously expressed. In the cell, the NWC protein which has been suggested to function as a transcriptional repressor, is found in the cytoplasm as well as in the nucleus.

4

Cyclolinopeptides and their analogs - a new family of peptide immunosuppressants affecting the calcineurin system

80%

Siemion I. Z., Cebrat M., Wieczorek Z.

Archivum Immunologiae et Therapiae Experimentalis

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1999

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tom 47

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nr 3

5

Synthesis and immunosuppressive activity of glycine containing linear analogs of cyclolinopeptide A

71%

Siemion I. Z., Cebrat M., Pedyczak A., Zimecki M., Wieczorek Z.

Archivum Immunologiae et Therapiae Experimentalis

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1993

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tom 41

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nr 5-6

6

Selection of a control reporter vector for the dual-luciferase reporter assay for transcription activation

71%

Matuszyk J., Ziolo E., Cebrat M., Kochel I., Strzadala L.

Cellular and Molecular Biology Letters

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2002

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tom 07

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nr Suppl.

7

Immunosuppressive activity of threonine-containing analogues of cyclolinopeptide A

71%

Siemion I. Z., Cebrat M., Lisowski M., Zimecki M., Wieczorek Z.

Archivum Immunologiae et Therapiae Experimentalis

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1992

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tom 40

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nr 5-6

8

On the peptide-antipeptide interactions in interleukin-1 receptor system

61%

Kluczyk A., Cebrat M., Zbozien-Pacamaj R., Lisowski M., Stefanowicz P., Wieczorek Z., Siemion I. Z.

Acta Biochimica Polonica

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2004

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tom 51

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nr 1

Interleukin-1 receptor antagonist (IL-1Ra) and vaccinia virus protein C10L share a VTXFYF motif, with X being Lys or Arg residue, respectively. Peptides of such sequence compete successfully with IL-1 for the cellular receptor. A pair of complementary peptides, based on the Siemion's hypothesis on the periodicity of the genetic code (QWLNIN and QWANIN), and another pair, in which, following the Root- Bernstein theory, Lys was used as complementary amino acid to Phe (QWLKIK and QWAKIK), were investigated for the peptide-antipeptide interactions using mass spectrometry (ESI-MS) and circular dichroism (CD) methods. The CD measurements indicated some conformational changes, more pronounced in the Siemion's pairs, however, no heterodimer formation was found by MS. In the region of IL-1 receptor situated close to the position of IL-1Ra in the IL-1Ra-receptor complex, a KQKL motif is present, suggesting a possibility of complementary recognition of the Root-Bernstein type in the IL-1 receptor. The biological activity of the complementary peptides is similar to that of the original ones. They efficiently compete with IL-1 and show moderate immunosuppressory activity in humoral and cellular immune response. The inhibition of the IL-1-IL-1 receptor interaction may result from the complementary peptides acting as mini-receptors with affinity for IL-1.

9

Search for the function of NWC, third gene within RAG locus: generation and characterization of NWC-deficient mice

42%

Kasztura M., Sniezewski L., Laszkiewicz A., Majkowski M., Kobak K., Peczek K., Janik S., Kapusniak V., Miazek A., Cebrat M., Kisielov P.

Archivum Immunologiae et Therapiae Experimentalis

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2016

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tom 64

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nr 4

Ograniczanie wyników

Rola szlaku sygnalowego Wnt i bialka APC w etiologii raka okreznicy

18th Polish Peptide Symposium

Identification of a novel protein encoded by third conserved gene within RAG locus

Cyclolinopeptides and their analogs - a new family of peptide immunosuppressants affecting the calcineurin system

Synthesis and immunosuppressive activity of glycine containing linear analogs of cyclolinopeptide A

Selection of a control reporter vector for the dual-luciferase reporter assay for transcription activation

Immunosuppressive activity of threonine-containing analogues of cyclolinopeptide A

On the peptide-antipeptide interactions in interleukin-1 receptor system

Search for the function of NWC, third gene within RAG locus: generation and characterization of NWC-deficient mice