Wyniki wyszukiwania

1

Badania i analiza czynnikow determinujacych efektywnosc pracy w malych szwalniach cholewek.

100%

Burzynska B., Grabkowski M.

Przegląd Skórzany

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2003

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tom 58

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nr 07-08

14-16

2

Wplyw wybranych czynnikow na wystepowanie niektorych schorzen dziedzicznych koni arabskich w Polsce

81%

Radomska M. J., Mieczkowska A., Burzynska B.

Przegląd Hodowlany

|

1992

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tom 60

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nr 08

25-27

3

Phylogeny and genetic variation of the European bison Bison bonasus based on mitochondrial DNA D-loop sequences

80%

Burzynska B., Olech W., Topczewski J.

Acta Theriologica

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1999

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tom 44

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nr 3

Genomic DNA from 14 representative animals of 3 maternal lines of Bison bonasus (Linnaeus, 1758) was used for amplification of a 1026-bp fragment of mtDNA D-loop. Analysis of this mitochondria! control region demonstrated only four variable sites in the studied B. bonasus population. Nucleotide substitutions in the fragment studied were very unstable, suggesting that intralineage sequence variation can occur in B. bonasus. To estimate phylogenetic relationships within the Bouinae subfamily mtDNA control region was analysed. The phylogenetic analysis separated two species of Bison, and placed Bison bison most closely to Bos grunniens. The rate sequence divergence of the hypervariable region of the D-loop between B. bonasus and B. bison was calculated as 78.5% per Myr.

4

Interindividual variability of atorvastatin treatment influence on the MPO gene expression in patients after acute myocardial infarction

51%

Sygitowicz G., Maciejak A., Piniewska-Juraszek J., Pawlak M., Gora M., Burzynska B., Dluzniewski M., Opolski G., Sitkiewicz D.

Acta Biochimica Polonica

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2016

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tom 63

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nr 1

5

Molecular analysis of three novel G6PD variants: G6PD Pedoplis-Ckaro, G6PD Piotrkow and G6PD Krakow

51%

Maciag M., Plochocka D., Jablonska-Skwiecinska E., Mendek-Czajkowska E., Golaszewska E., Strojny W., Balwierz W., Zdebska E., Burzynska B.

Acta Biochimica Polonica

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2007

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tom 54

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nr 4

877-881

We present three novel mutations in the G6PD gene and discuss the changes they cause in the 3-dimensional structure of the enzyme: 573C→G substitution that predicts Phe to Leu at position 191 in the C-terminus of helix αe, 851T→C mutation which results in the substitution 284Val→Ala in the β+α domain close to the C-terminal part of helix αj, and 1175T→C substitution that predicts Ile to Thr change at position 392.

6

Different statins produce highly divergent changes in gene expression profiles of human hepatoma cells: a pilot study

42%

Leszczynska A., Gora M., Plochocka D., Hoser G., Szkopinska A., Koblowska M., Iwanicka-Nowicka R., Kotlinski M., Rawa K., Kiliszek M., Burzynska B.

Acta Biochimica Polonica

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2011

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tom 58

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nr 4

Statins are inhibitors of 3-hydroxy-3-methylglutaryl-CoA reductase (HMGR), the key enzyme of the sterol biosynthesis pathway. Statin therapy is commonly regarded as well tolerated. However, serious adverse effects have also been reported, especially during high-dose statin therapy. The aim of our study was to investigate the effect of statins on gene expression profiles in human hepatoma HepG2 cells using Affymetrix Human Genome U133 Plus 2.0 arrays. Expression of 102, 857 and 1091 genes was changed substantially in HepG2 cells treated with simvastatin, fluvastatin and atorvastatin, respectively. Pathway and gene ontology analysis showed that many of the genes with changed expression levels were involved in a broad range of metabolic processes. The presented data clearly indicate substantial differences between the tested statins.

Ograniczanie wyników

Badania i analiza czynnikow determinujacych efektywnosc pracy w malych szwalniach cholewek.

Wplyw wybranych czynnikow na wystepowanie niektorych schorzen dziedzicznych koni arabskich w Polsce

Phylogeny and genetic variation of the European bison Bison bonasus based on mitochondrial DNA D-loop sequences

Interindividual variability of atorvastatin treatment influence on the MPO gene expression in patients after acute myocardial infarction

Molecular analysis of three novel G6PD variants: G6PD Pedoplis-Ckaro, G6PD Piotrkow and G6PD Krakow

Different statins produce highly divergent changes in gene expression profiles of human hepatoma cells: a pilot study