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Artykuł dostępny w postaci pełnego tekstu - kliknij by otworzyć plik
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Risk assessment for infants exposed to furan from ready-to-eat thermally processed food products in Poland

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Minorczyk M., Goralczyk K., Strucinski P., Hernik A., Czaja K., Lyczewska M., Korcz W., Starski A., Ludwicki J. K.
Roczniki Państwowego Zakładu Higieny
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2012
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tom 63
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nr 4
Background. Thermal processes and long storage of food lead to reactions between reducing sugars and amino acids, or with ascorbic acid, carbohydrates or polyunsaturated fatty acids. As a result of these reactions, new compounds are created. One of these compounds having an adverse effect on human health is furan. Objective. The aim of this paper was to estimate the infants exposure to furan found in thermally processed jarred food products, as well as characterizing the risk by comparing the exposure to the reference dose (RfD) and calculating margins of exposure. Materials and methods. The material consisted of 301 samples of thermally processed food for infants taken from the Polish market in years 2008 – 2010. The samples included vegetable-meat, vegetables and fruit jarred meals for infants and young children in which the furan levels were analyzed by GC/MS technique. The exposure to furan has been assessed for the 3, 4, 6, 9 ,12 months old infants using different consumption scenarios. Results. The levels of furan ranged from <1 μg/kg (LOQ) to 166.9 μg/kg. The average furan concentration in all samples was 40.2 μg/kg. The estimated exposures, calculated with different nutrition scenarios, were in the range from 0.03 to 3.56 μg/kg bw/day and exceeded in some cases RfD set at level of 1 μg/kg bw/day. Margins of exposure (MOE) achieved values even below 300 for scenarios assuming higher consumption of vegetable and vegetable-meat products. Conclusions. The magnitude of exposure to furan present in ready-to-eat meals among Polish infants is similar to data reported previously in other European countries but slightly higher than indicated in the recent EFSA report. As for some cases the estimated intake exceeds the RfD, and MOE) values are much lower than 10000 indicating a potential health concern, it is necessary to continue monitoring of furan in jarred food and estimate of its intake by infants.
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Development and validation of a method for determination of selected polybrominated diphenyl ether congeners in household dust

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Korcz W., Strucinski P., Goralczyk K., Hernik A., Lyczewska M., Czaja K., Matuszak M., Minorczyk M., Ludwicki J. K.
Roczniki Państwowego Zakładu Higieny
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2014
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tom 65
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nr 2
Background. Polybrominated diphenyl ethers (PBDEs) belong to group of so-called persistent organic pollutants (POPs). These compounds occur in nearly all elements of the environment, including household dust which constitutes one of a major route for human exposure. Their main adverse effects on human health are associated mainly with endocrine disruption – they interfere with thyroid function exhibit anti-androgenic action. Objectives. To develop and validate analytical method for determination of BDE-47, BDE-99, BDE-153, and BDE-209 congeners in household dust. Material and methods. Household dust was sampled in residences from Warsaw and the surrounding areas. An automated Soxhlet extraction of samples was then performed and PBDE congeners were subsequently measured in cleaned-up extracts by GC-μECD. The identity of quantified compounds was confirmed by GC/MS. Results. Household dust samples were fortified at levels of 2.88, and 28.8 ng g-1 for BDE-47, BDE-999, and BDE-153, and for BDE-209 at levels of 101.2, and 540 ng g-1. Recoveries ranged between 72 – 106%. The relative standard deviations (RSD) were less than 16% for all PBDE congeners analysed. The relative error determined on the basis of multiple analyses of certified reference material ranged from 1.07 – 20.41%. The method’s relative expanded uncertainty varied between 16 – 21%. Conclusion. The presented method was successfully validated and can be used to measure concentrations of BDE-47, BDE-99, BDE-153 and BDE-209 congeners in household dust.
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Validation of the analytical method for the simultaneous determination of selected polybrominated diphenyl ethers, polychlorinated biphenyls and organochlorine pesticides in human blood serum by gas chromatography with micro-electron capture detector

100%
Matuszak M., Minorczyk M., Goralczyk K., Hernik A., Strucinski P., Liszewska M., Czaja K., Korcz W., Lyczewska M., Ludwicki J. K.
Roczniki Państwowego Zakładu Higieny
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2016
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tom 67
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nr 2
Background. Polybrominated diphenyl ethers (PBDEs) as other persistent organic pollutants like polychlorinated biphenyls (PCBs) and organochlorine pesticides (OCPs) pose a significant hazard to human health, mainly due to interference with the endocrine system and carcinogenetic effects. Humans are exposed to these substances mainly through a food of animal origin. These pollutants are globally detected in human matrices which requires to dispose reliable and simple analytical method that would enable further studies to assess the exposure of specific human populations to these compounds. Objective. The purpose of this study was to modify and validate of the analytical procedure for the simultaneous determination of selected PBDEs, PCBs and OCPs in human blood serum samples. Material and Methods. The analytical measurement was performed by GC-μECD following preparation of serum samples (denaturation, multiple extraction, lipid removal). Identity of the compounds was confirmed by GC-MS. Results. The method was characterised by the appropriate linearity, good repeatability (CV below 20%). The recoveries ranged from 52.9 to 125.0% depending on compound and level of fortification. The limit of quantification was set at 0.03 ng mL-1 of serum. Conclusions. The modified analytical method proved to be suitable for the simultaneous determination of selected PBDEs, PCBs and OCPs in human blood serum by GC-μECD with good precision.
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