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1

Naltrexone-induced changes in m-opioid-receptor binding in neonatal rat brain following chronic prenatal hypoxia

100%
Kraczkowski J., Smolen A., Billewicz-Kraczkowska A., Semczuk M.
Polish Journal of Environmental Studies
|
2004
|
tom 13
|
nr Suppl.2, Part 1
Hypoxia experienced by the fetus is beli ved to be a major cause of disturbed CNS function during childhood. During perinatal hypoxia endogenous opioids are released in large amounts and the developing brain in the last week of gestation may be influenced by circulating opioids, down-regulates n-opioid receptors in neonatal brain. The opioid antagonist, Naltrexone (N) blocks opiate receptors in the brain after chronic administration and can result in either up- or down-regulation of opioid receptors in the brain structures. To test the hypothesis that Naltrexone prevents prenatal chronic hypoxia-induced changes in (i-opioid receptor system in developing brain, we quantified optical density of the (i-opioid receptors in several areas of newborn rat brain. In CPu and ZG cerebral structures of rats long-lasting anoxia leads to the decrease in optical density of ^-opioid receptors. Naltrexone prevents optical density of ^-opioid receptors in CPu, OT, MMPoA and LMPoA structures from decreasing.
2

Effect of MK-801 and acute prenatal hypoxia on optical density of mi-opioid receptors in developing rat brain

100%
Kraczkowski J., Smolen A., Billewicz-Kraczkowska A., Semczuk M.
Polish Journal of Environmental Studies
|
2004
|
tom 13
|
nr Suppl.2, Part 1
Hypoxia induces an elevation of excitotoxic amino acid concentrations and may influence hypoxic-in- duced basal ganglia injury. During pregnancy, hypoxia as the destructive factor of CNS alters concentration and mental retardation during childhood. The NMDA antagonist, MK-801, is known to block the effect of amino acids and protect the developing brain against hypoxic insults. To test the hypothesis that MK-801 change prenatal hypoxia affects on the optical density of the μ-opioid receptor system in the developing brain, we quantified optical density of the μ-opioid receptors in several areas of newborn rat brain. In the analysed cerebral structures of rats' brains short-lasting hypoxia leads to the decrease in optical density of n-opioid receptors. MK-801 lessens optical density of μ-opioid receptors in CPu, NA and LMPoA structures.
3

An analysis of stress coping in pregnant women with hypertension

88%
Kraczkowski J., Szymona K., Smolen A., Robak J., Semczuk M.
Polish Journal of Environmental Studies
|
2004
|
tom 13
|
nr Suppl.2, Part 1
Pregnancy-induced hypertension is a life threatening complication of pregnancy, both for a woman and for a child. The study aimed to evaluate models of coping with stress in a group of women with pregnancy hypertension. 30 women with pregnancy-induced hypertension were enrolled in the study. Authors made use of the Cattell Personality Factors test by K. Hirszl that assesses personality profiles and The Coping Inventory for Stressful Situations (CISS) by Endler&Parker in a Polish modification by P. Szczepaniak, K. Wrześniewski and J. Strelau. A high level of inner tension characterizes women with pregnancy-induced hypertension. Together with anxiety increase, escape from both contacts and discussing problems is observed in these women. Such situation may lead to secondary emotional agitation with a negative impact on both mother's and child's health state.
4

Obstetrical consequences and experienced anxiety in women with symptoms of imminent abortion

88%
Kraczkowski J., Smolen A., Szymona K., Krzyzanowski A., Semczuk-Sikora A.
Polish Journal of Environmental Studies
|
2004
|
tom 13
|
nr Suppl.2, Part 1
Psychological factors, such as anxiety, fatigue or stress, may influence the course of pregnancy and lead to spontaneous abortions. Psychological comfort is advised to increase symptoms regression and successful termination of pregnancy. The study aimed to evaluate the intensification and characteristics of anxiety in women with symptoms of imminent abortion and to analyze the relationship between anxiety and obstetrical complications. 30 pregnant women hospitalized with the diagnosis of imminent abortion symptoms were enrolled in the study as the group. Another 30 women with normal pregnancy were the control. Authors made use of the Cattell Personality Factor Test by K. Hirszl and The Self-Reported Anxiety Scale by C.D. Spielberg, R.L. Gorsucha and R.E. Lushene. High level of anxiety that accompanies symptoms of imminent abortion is believed to be a secondary risk factor for preterm pregnancy termination.
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