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On the basis of the publications (18 works published and 4 prepared for publishing) the author describes the activities of the Katowice centre. The District Dispensary of Immunopathology of Pregnancy and Newborn joined the I Clinic of Gynecology and Diseases of Women of the Silesia Medical Academy to work on trichomonadosis and in this respect it takes advantage also of the considerable experience in this field gained by the District Department of Veterinary Hygiene. The range of infection of women in the Katowice province is from 13.9% to 29%. The isolation of the Trichomonas vaginalis renders no greater difficulties in connection with the improved diagnostic methods. The treatment, however, remains still problematic.
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63%
T. vaginalis was found in 21.8% out of 320 parturient women in the Clinic; in 91% of the pregnant infested with T. vaginalis there were inflammatory manifestations of the vagina during pregnancy. In the puerperium, the infested women often showed longstanding temperature rises. The reasons accounting for the febrile course of the puerperium in women infested with T. vaginalis are discussed.
A mixed Flagyl therapy was applied in 18 women at various stages of pregnancy and in different health conditions in whom direct examination showed the presence of T. vaginalis in the vaginal discharge: they were hospitalized during the treatment and sampling of control smears. In 9 cases, the pregnancy terminated in the full term birth of living babies without any malformations; the course of labour and puerperium was uneventful; one pregnancy terminated in premature stillbirth; this woman was affected by syphilis. One woman, treated because of impending miscarriage after the effective treatment of trichomonadosis, had a prolonged labour. During the treatment all pregnant women showed the disappearance of clinical symptoms related to the presence of T. vaginalis, both in acute and subacute forms. The drug tolerance was good. The control smears after the treatment were found to contain no T. vaginalis.
An attempt was undertaken to elucidate the role of RES in a treatment of toxoplasmosis, as applied in the I Clinic of Obstetrics and Gynecology of the Medical School in Zabrze. Using histopathologic and histochemical methods in various experimental systems in animals, the functional state of RES was determined in the liver, lungs, spleen and thymus. Parallel determinations were concerned with the survival rate of animals infected with toxoplasmosis after stimulation (panodine, BCG) and blockade of RES (colloid carbon, trypan blue). A correlation was found to exist between the functional state of RES and the course of toxoplasma infection and the role of the former during the treatment is discussed.
At the Ist Clinic of Obstetrics and Gynecology of the Silesian Medical Academy in Zabrze 40 women with the symptoms of acute and subacute trichomonadosis of the uro-genital tract were subjected to tile treatment with Thiofastil and Aminitrozol; the former was administered in tablets by intravaginal route, 1 daily for 10 days; Aminitrozol was given paralelly in tablets per os in the amount of 0.1 g 3X a day, for 10 days. If needed, the combined treatment was repeated increasing the dosis of Thiofastil up to 20 tablets (1 tablet twice daily for 10 days). In 22 cases, Aminitrozol was also employed to treat the sexual partners. The percentage of cures was 62.5%. We have considered the patients to be entirely cured when repeatedly checked discharges from the urethra, vagina and uterine cervix did not show the presence of T. vaginalis in the saline drop, as well as in the smears stained according to Giemsa. In non-cured patients there was a considerable improvement: diminution in the vaginal discharge, disappearance of vulvar oedema and of pruritus and burning sensations. Microscopic picture was consistent with this condition, showing a reduced number of leucocytes and T. vaginalis. The percentage of cures obtained by this combined method is higher as compared with that observed after the separate use of Thiofastil and Aminitrozol in two groups of women.
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In 1961-1962, the examinations of 225 pregnant women suspected of having toxoplasmosis revealed positive serologic and allergic reations in 93 cases; 67 women were subjected to prophylactic treatment (daraprim, sulphonamides, aureomycin); 62 women delivered of living babies, born at term, 4 had abortions and 1 prolonged labour terminated with still birth. The follow-up examinations in 52 mothers revealed no abnormalities except for positive complement fixation reaction in 7 eases.
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